Genetically engineered mice will play a very important role in future studies of liver function, and so it is vitally important to have baseline reference information on the cellular makeup of normal mouse liver.

2024年4月16日 · We have combined Stereo-seq (spatiotemporal enhanced resolution omics-sequencing) with single-cell transcriptomic profiling of 473,290 cells to generate a high-definition spatiotemporal atlas of...

This Digitized Atlas of Mouse Liver Lesions provides color photomicrographs illustrating examples of some spontaneous, aging as well as chemically induced non-neoplastic and neoplastic histopathological hepatobiliary lesions commonly observed in B6C3F1 and Genetically Modified mice from acute, subchronic and chronic toxicity and/or ...

Primary hepatocytes are a vital tool in various biomedical research disciplines, serving as an ex vivo model for liver physiology. Obtaining high yields of viable primary mouse hepatocytes is technically challenging, limiting their use. Here, we present an improved protocol based on the classic two-step collagenase perfusion technique.

Chronic liver diseases (CLD) result in 1.03 million deaths per year worldwide. A lethal complication in CLD is the development of multi-organ failure, particularly renal failure.

2024年6月7日 · Upon heterotopic transplantation into the mesentery of tyrosinemia or 90% hepatectomy mice, our 3D-bioprinted liver effectively restored lost liver functions, consequently …

2024年11月28日 · Here, we report that chronic stress impairs the liver regeneration capacity after partial hepatectomy with increased mortality in male mice.

2025年3月14日 · The mouse liver is a key organ in biomedical research due to its similarities to the human liver in metabolism, disease progression, and drug response. Its distinct lobes play vital roles in physiological processes, making their anatomy and function essential to understand. Examining the liver’s lobes reveals differences in tissue organization, circulation, gene …

The cellular organization of normal mouse liver was studied using light and electron microscopy and quantitative immunocytochemical techniques. The general histological organization of the mouse liver is similar to livers of other mammalian species, with a lobular organization based on the distributions of portal areas and central venules.

2020年6月5日 · Here, we address these issues by exploiting multidimensional imaging technologies to study structural and functional dynamics of the biliary system in mouse models of liver injury.