2025年2月9日 · Primary fibroblast cultures and tissues from Rb1 (deltaG) mice exhibit derepression of direct pRB-E2F transcriptional targets and yet maintain the ability to control …

2004年2月29日 · To complement and extend the explant culture studies in vivo, we inactivated the gene Rb1 in the retina by using a new tissue-specific Cre transgenic line (Chx10-cre) …

Here we report that inactivation of pRb target Skp2 (refs. 7,8) completely prevents spontaneous tumorigenesis in Rb1(+/-) mice. Targeted Rb1 deletion in melanotrophs ablates the entire …

2006年8月28日 · Heterozygous Rb1 null mice develop normally, but spontaneously develop pituitary tumors of the intermediate and anterior lobes as well as medullary thryroid …

2017年1月6日 · Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional …

2016年10月14日 · Here, we show by CRISPR/Cas9 techniques that similar to the mouse, neither rb1 nor rbl1 single mosaic mutant Xenopus tropicalis develop tumors, whereas rb1/rbl1 double …

2015年2月23日 · We have generated an inducible RB1 DN transgenic mouse model that combines the straightforward strategy of the Dox-dependent transcriptional system to the …

2015年8月14日 · To study the induction of genomic imprinting of mouse Rb1 by introduction of a proven human gDMR, we generated Rb1_PPP1R26P1 knock-in mice to pass the human …

View mouse Rb1 Chr14:73430298-73563446 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression

The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene identified in humans (Friend, et al., 1986) and the first tumor suppressor gene knocked out by targeted …