2023年10月12日 · In this work, we comprehensively map the antigenic profiles of multiple human and mouse-neutralizing sera to a model human picornavirus, coxsackievirus B3 (CVB3). Our results reveal a conserved...

2023年9月19日 · This study suggests that administration of POMVs immunized adult mice sera downregulated the production of IL-6, IL-1β, TNF-α, IFN-γ, IL-12p40/70 and IL-23 pro-inflammatory cytokines in neonatal mice small intestines after challenge with DEC subtypes, leading to attenuation of inflammation.

2024年8月20日 · We find that long-term Pkm2 modulation induces timely competition alteration and hysteretic rank change, through phosphorylating the Ser845 site of GluA1. Together, this study uncovers a crucial...

2024年5月15日 · In mice, a single dose of a preclinical version of mRNA-1273 vaccine encoding Wuhan-1 spike protein minimally imprinted serum responses elicited by Omicron boosters, enabling generation of type...

2020年3月31日 · The sera from MERS-PsV-treated mice, as negative control, did not reach our NT 50 threshold at a dilution of 1:100 and did not show a significant difference (P > 0.5) compared with the PBS-treated control group. Then, we tested the neutralization effects of the sera against MERS-PsV infection using the Huh-7 cell line.

Standard sera, singly positive for antibodies to individual infectious agents, were generated by inoculation of BALB/cj and C57BL/6j mice. Sera from these experimentally infected mice, as well as sera from naturally infected mice, were analyzed using a mixture of microbeads coated with antigens of the 10 infectious agents listed above.

2024年7月18日 · In this study, FHA’s mature C-terminal domain (MCD) was evaluated as a novel vaccine antigen. MCD was conjugated to virus-like particles via SpyTag-SpyCatcher technology. Prime-boost vaccine studies were performed in mice to characterize immunogenicity and protection against the intranasal B. pertussis challenge.

We determined the ability of the individual sera to inhibit in vitro fertilization and to bind to sperm antigens separated by electrophoresis. Compared to preimmune sera, four of five immune sera significantly inhibited in vitro fertilization. The serum from individual mice bound variable panels of sperm antigens.

Naïve control sera of non-immunized animals. Data are shown for the individual sera (colored crosses) and as means and standard deviations. The types of mouse sera are shown on the X-axis.

Sera and sera-derived products derived from mice. Suitable for multiple scientific and educational research purposes.