A mouse model of TSC2 was generated by AAV-Cre recombinase disruption of Tsc2-floxed alleles at birth, leading to a shortened lifespan (mean 58 days) and brain pathology consistent …

1999年9月15日 · We have generated an inactivated allele of the Tsc2 gene in mice, demonstrated that Tsc2 –/– is embryonic lethal, and shown that the Tsc2 +/– mice develop a diverse set of …

027458 STOCK Tsc2 tm1.1Mjg /J These floxed mutant mice possess loxP sites flanking exons 2, 3 and 4 of the Tsc2 gene. This strain may be useful for generating conditional mutations in …

004686 B6;129S4- Tsc2 tm1Djk /J Tsc2+/- mice are useful in studying Tuberous sclerosis. In addition, the mTOR hyperactivation exhibited by Tsc2+/- mice causes impaired basal neuronal …

该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Tsc2基因的小鼠模型。 *使用本品系发表的文献需注明: Tsc2-Flox mice (Cat. NO. NM-CKO-2102032) were …

2024年9月23日 · To critically define the role of the TSC complex as a downstream target of AKT in the control of tissue and organismal mTORC1 signaling, we generated two novel knock-in …

Following 2 months of treatment of Tsc2 +/− mice from the age of 12 months, combination of 3-BrPA and CB-839 significantly reduced overall size and cellular areas of all renal lesions …

2021年1月8日 · A mouse model of TSC2 was generated by AAV-Cre recombinase disruption of Tsc2-floxed alleles at birth, leading to a shortened lifespan (mean 58 days) and brain …

2025年2月11日 · Presynaptic GABAB receptor-mediated network excitation in the medial prefrontal cortex of Tsc2(+/-) mice. Aberrant mTOR/autophagy/Nurr1 signaling is critical for …

View mouse Tsc2 Chr17:24814790-24851604 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression