Severely dehydrated mice will be weak and often will look paralyzed in their rear legs. These mice may also have trouble gripping the cage bars with their forefeet. Other symptoms of severe dehydration include sunken or recessed eyes and fuzzy facial …

2014年9月18日 · The Tokyo group gave the treatment to mice with a rodent form of Emery-Dreifuss muscular dystrophy (EDMD), an inherited disease in humans involving a defect in a gene for a muscle protein that also leads to abnormal neuromuscular junctions and …

2022年8月16日 · To establish a mouse model of weak depression, we raised six-week-old C57BL/6N mice in single (SH) or group housing (GH) conditions for two weeks. The SH group showed less social interaction with stranger mice, learning disability in behavioral tests, and lower plasma corticosterone level.

2022年5月11日 · Here, we recorded local field potential signals from multiple brain regions covering the forebrain in young (10-week-old) and aged (2-year-old) mice. Interregional LFP correlations across these...

2022年5月19日 · To establish a mouse model of weak depression, we raised 6-week-old C57BL/6N mice in single (SH) or group housing (GH) conditions for 2 weeks. The SH group showed less social interaction with stranger mice, learning disability in behavioral tests, and lower plasma corticosterone levels.

Genetic weakening occurs with mice raised in a safe (captive) environment. When mice are protected from the natural culling of the wild, genetically "weak" mice survive long enough to reproduce and pass their genes on. Even in one generation you can start to pick out the mice that wouldn't survive in the wild.

1998年11月30日 · Increased numbers of mice—some with potentially debilitating phenotypes—are being maintained to their natural life spans, and this has chal- lenged the laboratory animal community to devise...

2025年2月12日 · Researchers found that MuSK assembles sodium channels, which amplify muscle contraction signals from the neurotransmitter acetylcholine. They discovered this role for MuSK when they removed a critical piece of the protein in mice and disrupted the amplifier – which weakened the contractions.

2024年11月15日 · In the PS19 transgenic mouse, weak increase of glial fibrillary acidic protein (GFAP), a marker for astroglia cells, could be detected throughout brain at 3-month-old age, while marked increase of GFAP was observed in 6 month old PS19 mice 32. We then examined the ability of ANKHD1 to suppress glial activation caused by the mutant Tau protein ...

SCID mice are deficient in T and B lymphocytes, but retain natural killer (NK) cells and show “leakage” (4). The SCID mutation was then introduced into non-obese diabetic (NOD) mice with NK cell defects to obtain NOD/SCID mice (5), forming the third stage of immunodeficient mice.