Misshapen-like kinase 1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family.

2024年12月25日 · MINK1 (Misshapen Like Kinase 1) is a Protein Coding gene. Diseases associated with MINK1 include Myasthenic Syndrome, Congenital, 4B, Fast-Channel and Myasthenic Syndrome, Congenital, 4A, Slow-Channel. Among its related pathways are Cellular responses to stimuli and Cellular Senescence.

该基因编码属于生发中心激酶 (GCK) 家族的丝氨酸/苏氨酸激酶。 该蛋白在结构上类似于与 NIK 相关的激酶，并且可能属于 GCK 家族中 NIK 相关激酶的一个独特亚家族。 对小鼠同系物的研究表明，在出生后小鼠大脑发育过程中表达上调，cJun N 末端激酶 ( JNK) 和 p38 通路激活。 [RefSeq 提供，2016 年 3 月] This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family.

2024年12月5日 · MINK1 plays an important role in immunological responses, inhibiting Th17 and Th1 cell differentiation and regulating NLRP3 inflammasome function. It may be considered a link between ROS and the immunological system, and a potential antiviral target for …

2025年2月9日 · Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis. MINK1 interacts with and phosphorylates PRICKLE1 and PRICKLE2.

MINK1 deficiency reduced NLRP3 activation and suppressed inflammatory responses in mouse models of acute sepsis and peritonitis. Reactive oxygen species (ROS) upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.

MINK1 deficiency protects cartilage from degeneration in aging joints through increased SMAD2 activation in chondrocytes, while accelerating OA progress in injury-induced model through enhanced osteogenesis of MSCs in the subchondral bone. These findings provide insights for developing precision OA therapeutics targeting TGFβ/SMAD2 signaling.

在这里，使用基于 crispr/cas9 的激酶组敲除筛选，畸形样激酶 1 (mink1) 被确定为 oscc 中 5fu 耐药性的重要介质。 临床样本分析表明，与化疗应答者相比，化疗无应答者的肿瘤组织中 MINK1 表达显着更高。

Mink1是利用SAGE（serial analysis of gene expression）方法，在CD4+ T细胞中筛选到的高表达基因，其编码了一个丝氨酸/苏氨酸激酶。 早期研究通过RNAi技术显示MINK1参与了T细胞的阴性选择过程。

与人类 mink1 同源（畸形像激酶 1）。 [由基因组资源联盟提供，2022 年 4 月] Enables ATP binding activity and protein serine/threonine kinase activity.