The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. The microRNA precursor miR-17 family, includes miR-20a/b, miR-93, and miR-106a/b.

2017年2月16日 · We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genetic deletion of the miR-17 ∼ 92 cluster inhibits cyst proliferation and PKD progression in four orthologous,...

2013年11月11日 · Herein, we focus on the miR-17/92 cluster of miRNAs and review the current knowledge to date as to the roles of its members in health and disease. In light of recent findings, we also examine and...

2024年12月25日 · MIR17 (MicroRNA 17) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR17 include B-Cell Lymphoma and Pulmonary Hypertension. Among its related pathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. ...

甲状腺间变性癌 (ATC) 是一种侵袭性、高转移性的癌症，表达高水平的 microRNA (MiR)17-92 簇。 作者利用 miR 抑制系统，基于 ATC SW579 细胞系中种子序列的同源性，研究了 miR-17-92 簇内不同 miR 的功能。 虽然四个 miR-17-92 家族中有三个是致癌的，但作者发现了 miR-17 在体内外作为 肿瘤 抑制因子的新作用。 图片来源: https://doi.org/10.1016/j.omtn.2021.10.021.

2013年6月30日 · Our results identify the miR-17 ∼ 92 cluster as a critical regulator of T cell–dependent antibody responses, T FH cell differentiation and the fidelity of the T FH cell gene-expression program.

2025年2月8日 · Long Noncoding RNA HAND2-AS1 Suppresses Cell Proliferation, Migration, and Invasion of Bladder Cancer via miR-17-5p/KLF9 Axis. MiR-17 approximately 92 is involved in NF-kappaB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL.

微小RNA(microRNA,miRNA)是一类内源性的非编码的高度保守的单链小分子 RNA,通过完全和(或)部分互补的原则结合到靶基因3′UTRs或者直接剪切靶基因mRNA,以降解或抑制mRNA翻译的方式调控靶基因的表达. miR-17-92基因簇位于人染色体13q31.3处,可产生miR …

MiR-17-92是一个高度保守的基因簇，该基因簇主要有6个成员，包括miR-17，miR-18a，miR-19a，miR-20a，miR-19b-1和miR-92a。 这些基因通过调控靶基因参与肿瘤的发生、发展，参与一些细胞的免疫反应，并在内分泌系统中发挥一定的作用。

2017年2月16日 · We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genetic deletion of the miR-17∼92 cluster inhibits cyst proliferation and PKD progression in four orthologous, including two long-lived, mouse models of ADPKD.