We show further that upregulation and downregulation of miR-218 levels specifically in the mPFC correlate with miR-218 expression in blood. Our results suggest that miR-218 in the adult …

研究团队通过CRISPR/Cas9基因编辑技术构建miR-218-1和miR-218-2 基因敲除小鼠 ，揭示了miR-218在大脑中广泛表达，尤其是在海马中表达水平最高；而敲除miR-218-2基因后，miR-218在 …

2015年7月27日 · Here the authors demonstrate that miR-218 is an essential component of the gene regulatory network that controls motor neuron fate specification in the developing spinal …

2021年4月6日 · microRNA-218 (miR-218) has been linked to several cognition related neurodegenerative and neuropsychiatric disorders. However, whether miR-218 plays a direct …

2019年4月12日 · Our results suggest that miR-218 in the adult mPFC might function as a molecular switch that determines susceptibility vs. resilience to chronic stress, and that stress …

在本研究中，作者通过CRISPR/Cas9技术构建miR-218-1和miR-218-2基因敲除小鼠，揭示了miR-218在大脑中广泛表达，尤其是在海马中表达水平最高；而敲除miR-218-2基因后，miR-218在 …

2015年7月27日 · Here we show that in the developing spinal cord, the expression of miR-218 is directly upregulated by the Isl1-Lhx3 complex, which drives motor neuron fate. Inhibition of …

2017年1月3日 · In this study, we have determined that miR-218 serves as crucial constituent regulator in neuronal differentiation of adipose stem cells (ASCs) through Wnt signaling …

miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding. miR-218 appears to be a vertebrate specific microRNA and has now been …

One such miRNA is miR-218, which is debated as a critical candidate for increased stress susceptibility. miR-218 is expressed throughout the brain, notably in the hippocampus and …