MIR30B RNA Gene - GeneCards
2024年12月25日 · MIR30B (MicroRNA 30b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30B include Medulloblastoma and Hodgkin's Lymphoma. Among its related pathways is miRNA targets in ECM and membrane receptors. ... Control Lentivectors and Lentiviruses with GFP, RFP, and Luciferase also available.
Nature子刊丨上海药物所任进团队揭示核miR-30b-5p抑制TFEB介 …
2020年8月6日，中国科学院上海药物研究所任进、陶周腾、黄锐敏课题组在Nature旗下期刊CDD: Cell Death & Differentiation（IF10.717）上发表题为Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy的研究文章。报道了核miR-30b-5p通过将TFEB的结合基序定位于含有CLEAR ...
407030 - Gene ResultMIR30B microRNA 30b [ (human)]
2025年2月8日 · MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 expression in gastric cancer cells. overexpression of miR-30b can improve the Hcy-induced apoptosis in HCAECs by downregulating caspase-3 expression. Therefore, miR-30b may play an important role in Hcy-induced apoptosis in endothelial cells
miR-30 Family: A Promising Regulator in Development and Disease
The microRNA-30 (miR-30) family is an important member of miRNA family, which contains five members and 6 mature miRNA molecules (namely, miR-30a, miR-30b, miR-30c-1, miR-30c-2, miR-30d, and miR-30e) and is encoded by six genes located on human chromosome 1, 6, and 8 .
Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal
2020年8月6日 · In this study, we found that nuclear miR-30b-5p suppressed the transcriptional activity of TFEB by targeting its binding motif at the gene promoter regions containing the CLEAR element to inhibit...
新版miR-30b生物学功能研究进展汇编 - 豆丁网
2021年3月3日 · miR-30家族成员包括miR-30a、-30b、-30c、-30d、-30e和-384-5p。在人类肿瘤中，miR-30b已被证实是一种在癌症发病机制中起着重要作用的肿瘤抑制基因，但在少数情况下发挥类似致癌基因的作用[3-4]。本文拟对miR-30b在肿瘤发生发展过程中的作用机制进行综述。
上海药物所发现miR-30b-5p在细胞核内抑制TFEB介导的溶酶体生 …
2020年8月10日 · 8月6日，中国科学院上海药物研究所安全评价研究中心主任、研究员任进团队在《自然》（Nature）旗下期刊CDD: Cell Death & Differentiation上，发表题为Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy的研究文章。该研究通过RNA-seq、蛋白质谱分析、CRISPR/Cas9 ...
miR-30b通过抑制NLRP3炎症小体激活降低心肌缺血再灌注损伤研 …
摘要 目的:探究miR-30b通过靶向抑制NLRP3炎症小体的激活来降低心肌缺血再灌注大鼠心肌损伤的作用机制。方法:选取50只SD大鼠纳入研究,随机将大鼠分为Sham组(假手术组)、MIRI组(模型组)、miR-30b mim...
miR-30b-3p Inhibits Proliferation and Invasion of Hepatocellular ...
2019年12月13日 · Results: Expression of miR-30b-3p was markedly decreased in HCC tissues and cells and positively correlated with higher overall survival. Moreover, miR-30b-3p overexpression significantly repressed cell viability, proliferation, migration, …
肠癌组织中的miR-30b-5p 表达水平显著降低(P ＜ 0. 001)，见图1A;结直肠癌患者血清中的miR-30b-5p 水平明显低于正常人血清中的miR-30b-5p 含 量，见图1B;结直肠癌细胞Caco-2、HT-29 及HCT-116 中的miR-30b-5p 表达量显著低于正常结肠细胞 系NCAM460 中的表达量(P ＜0. 05)，见 …