miRNA Inhibition in Tissue Engineering and Regenerative Medicine
Therapeutic inhibition of miRNA represents a relatively unexplored but potentially powerful approach to modulate stem cell differentiation, to control host cell function as they infiltrate …
MicroRNAs and small interfering RNAs can inhibit mRNA …
2003年8月5日 · Here, we demonstrate that an endogenously encoded human miRNA is able to cleave an mRNA bearing fully complementary target sites, whereas an exogenously supplied …
microRNA inhibitors: Natural and artificial sequestration of microRNA …
2017年10月28日 · Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of …
Anti-miRNA oligonucleotides: A comprehensive guide for design
New classes of chemical-modified-AMOs, including locked nucleic acid oligonucleotides, have recently proved their worth in silencing miRNAs. A correct design of a specific AMOs can help …
The mechanics of miRNA-mediated gene silencing: a look …
2012年6月5日 · This Review describes recent advances, with an emphasis on how the miRNA-mediated silencing complex (miRISC) controls gene expression by inhibiting translation and/or …
microRNA inhibitors: Natural and artificial sequestration of ... - PubMed
2017年10月28日 · Artificial miRNA inhibitors are RNA transcripts that are synthesized via chemical and genetic methods. Artificial miRNA inhibitors can be used in miRNA loss-of …
Overview of MicroRNA Biogenesis, Mechanisms of Actions, …
The target specificity of miRISC is due to its interaction with complementary sequences on target mRNA, called miRNA response elements (MREs). The degree of MRE complementarity …
MicroRNAs inhibit the translation of target mRNAs on the …
2013年4月25日 · Translation inhibition is a major but poorly understood mode of action of microRNAs (miRNAs) in plants and animals. In particular, the subcellular location where this …
MicroRNAs and their targets: recognition, regulation and an
2012年3月13日 · In plants and animals, miRNAs usually repress target expression by inducing mRNA deadenylation and degradation or by inhibiting translation. Many factors, including …
Regulation of mRNA translation and stability by microRNAs
In this review, we describe principles of miRNA-mRNA interactions and proteins that interact with miRNAs and function in miRNA-mediated repression. We discuss the multiple, often …