Mitochondrial regulation of GPX4 inhibition–mediated ... - Nature
2023年12月26日 · We found that the mitochondria-specific CoQ potently inhibited GPX4 inhibition–mediated ferroptosis, suggesting that mitochondrial lipid redox regulates ferroptosis …
Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia
2022年11月15日 · We here study targeting ferroptosis pathway in AML and its mitochondrial (mito-) regulation to develop mechanism-based combination with mito-targeting agents. …
AML-250 Mitochondrial Respiration Regulates GPX4 Inhibition …
2022年10月1日 · As a potentially AML-specific mechanism that is unusual in solid tumor models, we found that GPX4 inhibition-induced ferroptosis was efficiently blocked by the mitochondria …
Mitoquinone protects against acetaminophen-induced liver injury …
2023年4月15日 · MitoQ, an analog of coenzyme Q10, is targeted towards mitochondria and acts as a potent antioxidant. This study aimed to explore the effect of MitoQ on APAP-induced liver …
STTT | 中山大学肿瘤医院：肿瘤细胞通过微环境中反应信号获得干 …
2023年8月11日 · 清除mROS的线粒体靶向抗氧化剂（MitoTempo或MitoQ）用于恢复线粒体功能。 事实上，MitoTempo和MitoQ都恢复了ATF1缺失细胞中的核周线粒体定位。 在ATF1缺乏的细 …
Mitochondrial metabolism as a target for acute myeloid leukemia ...
2021年4月21日 · Druggable mitochondrial targets in AML cell and selected pharmacological agents. A depiction of mitochondria, showing important biochemical targets (e.g., the citric acid …
The antimicrobial peptide PFR induces necroptosis mediated by
2019年10月4日 · The mitochondrial-targeted antioxidant MitoQ both decreased elevated mitochondrial ROS levels (Fig. 1i) and increased cell proliferation and viability (Fig. 1j) in the …
Mitochondrial metabolism as a target for acute myeloid leukemia ...
2021年4月21日 · Proliferation of the myeloblasts generates a bulk of largely non-functional cells, compromising hematopoiesis, leading to neutropenia and increasing vulnerability to infectious …
Pharmacological significance of MitoQ in ameliorating …
2022年7月1日 · MitoQ demonstrated these promising effects by inhibiting the activation of the NLRP3 inflammasome, blocking mtROS, and upregulating the expression of M2 markers in …
MitoQ在对乙酰氨基酚诱导的肝细胞铁死亡中的保护作用及机制研 …
因此本研究拟评估线粒体活性氧（mitochondrialROS，mtROS）在APAP诱导肝细胞铁死亡中的作用，观察线粒体靶向抗氧化剂MitoQ对APAP诱导肝细胞铁死亡的保护作用。 研究方法： 一、 …