Cytochrome c is an essential component of the respiratory electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the bc 1 Complex III and transports them to Complex IV, while it transfers energy in the opposite direction. [citation needed]

2006年5月5日 · Cyt c, a peripheral protein of the mitochondrial inner membrane (IM), functions as an electron shuttle between complex III and complex IV of the respiratory chain and its activity is necessary...

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy conditions, produces ROS with the co-factor p66Shc, and oxidizes ...

Biogenesis of c-type cytochromes involves covalent attachment of heme to two cysteines (at a conserved CXXCH sequence) in the apocytochrome. Heme attachment is catalyzed in most mitochondria by holocytochrome c synthase (HCCS), which is also necessary for import of apocytochrome c.

In this study, with isolated liver mitochondria, we demonstrate that cytochrome c release requires a two-step process. Because cytochrome c is present as loosely and tightly bound pools attached to the inner membrane by its association with cardiolipin, this interaction must first be disrupted to generate a soluble pool of this protein.

Cytochrome c is one of the mitochondrial proteins that is released into the cytosol when the cell is activated by an apoptotic stimulus. In the cytosol, cytochrome c engages the apoptotic...

2020年4月1日 · Under conditions of cellular stress, Cyt c release from the mitochondria is a committing step for apoptosis, leading to apoptosome formation, caspase activation, and cell death. Recently, Cyt c was shown to be a target of cellular signaling pathways that regulate the functions of Cyt c by tissue-specific phosphorylations.

2024年3月23日 · In the mitochondria, cytochrome c acts as an electron carrier in the electron transport chain, facilitating adenosine triphosphate synthesis, regulating cardiolipin peroxidation, and...

2017年5月31日 · We investigate functional role of the P 76 GTKMIFA 83 fragment of the primary structure of cytochrome c. Based on the data obtained by the analysis of informational structure (ANIS), we propose a model of functioning of cytochrome c.

2002年1月29日 · In this study, we provide evidence that the release of cytochrome c from mitochondria requires a two-step process, consisting of the detachment of this protein from its membrane-anchoring lipid, cardiolipin, followed by permeabilization of the outer mitochondrial membrane, permitting the release of cytochrome c into the extramitochondrial ...