Mitochondria and cell death - Nature Cell Biology
2024年6月20日 · We highlight the emerging theory that non-lethal mitochondrial apoptotic signalling has diverse biological roles that impact cancer, innate immunity and ageing.
Mitochondrial Regulation of Cell Death - PMC
Here we discuss the mechanisms underlying mitochondrial permeabilization and how this key event leads to cell death through caspase-dependent and -independent means. We then proceed to explore how the release of mitochondrial proteins may be regulated following MOMP.
Mitochondria as multifaceted regulators of cell death
2019年10月21日 · In this Review, we discuss new insights into how mitochondria regulate apoptotic cell death. Surprisingly, recent data demonstrate that besides eliciting caspase activation, MOMP engages various...
Cell death: All roads lead to mitochondria - Cell Press
2022年8月22日 · The mitochondrial, or ‘intrinsic’, apoptotic pathway is activated when the permeabilized mitochondrial membrane of stressed cells releases apoptotic effectors. A new study now characterizes how mitochondria are involved in the switch from pyroptotic to necroptotic cell death.
Mitochondria and cell death-associated inflammation
2022年11月29日 · Permeabilised mitochondria trigger inflammation, in part, through the release of mitochondrial-derived damage-associated molecular patterns (DAMPs). Caspases, while dispensable for cell death...
Mitochondria: Regulators of Cell Death and Survival - PMC
The past 5 years has seen an intense surge in research devoted toward understanding the critical role of mitochondria in the regulation of cell death. Apoptosis can be initiated by a wide array of stimuli, inducing multiple signaling pathways that, for …
Mitochondria Related Cell Death Modalities and Disease - PMC
In this review, we discuss how mitochondria are involved in modes of cell death, as well as basic research and the latest clinical progress in related fields.
Mitochondria as multifaceted regulators of cell death - PubMed
In this Review, we discuss new insights into how mitochondria regulate apoptotic cell death. Surprisingly, recent data demonstrate that besides eliciting caspase activation, MOMP engages various pro-inflammatory signalling functions.
Mitochondrial regulation of cell death: a phylogenetically …
2016年3月3日 · Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.
Dynamic death decisions: How mitochondrial dynamics shape …
Mitochondrial crosstalk with numerous regulated cell death (RCD) pathways controls the decision to die. In this review, we will focus on apoptosis and ferroptosis, two distinct forms of RCD that utilize divergent signaling to kill a targeted cell.