Mitophagy: Mechanisms and Role in Human Disease - PMC
Mitophagy is a selective form of macro-autophagy in which mitochondria are specifically targeted for autophagic degradation. Mitophagy plays an important role in cellular homeostasis by …
Mitophagy reporters. Schematic detailing the different …
In this review, we compiled current studies investigating the role of BNIP3, DRAM1, and FUNDC1, mediators of receptor-mediated mitophagy, in the progression of preeclampsia and the role of ...
Models for regulating mitochondrial morphology and mitophagy …
(A) Schematic diagram of mitochondrial fission and fusion. Mitochondria usually take on various forms, and fission usually occurs before mitophagy. Fragmented mitochondria...
Mitophagy in human health, ageing and disease - Nature
2023年11月30日 · We outline mitophagy’s role in specific diseases and describe mitophagy-activating approaches successfully tested in humans, including exercise and nutritional and …
Schematic illustration of three mitophagy pathways (left to right ...
The removal of damaged mitochondrial components through a process called mitochondrial autophagy (mitophagy) is essential for the proper function of the mitochondrial network. …
Mitophagy pathway overview: PINK1, Parkin, autophagy | Abcam
2021年5月16日 · In mammals, the mitophagy pathway involves PTEN-induced putative protein kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin. Learn the role of PINK1, Parkin, and the …
Mitophagy：Mechanisms and Detection - MedChemExpress
Mitophagy is a type of selective autophagy that specifically targets organelles. In previous discussions, we have covered the classification, substrates, and detection of autophagy. Now, …
Mechanisms and Physiological Roles of Mitophagy in Yeast
2018年1月1日 · Mitophagy in yeast (A) Schematic representation of autophagy. When autophagy is induced, isolation membranes nucleate at the preautophagosomal structure/phagophore …
In Brief: Mitophagy: mechanisms and role in human disease
2016年7月25日 · Schematic diagram illustrating the mechanisms and role of mitophagy in disease. PINK1/Parkin-mediated mitophagy promotes the elimination of depolarized …
The interplay between mitochondrial dynamics and mitophagy
2011年5月15日 · A schematic illustration of the mitochondrion's life cycle and the roles of mitochondrial dynamics and autophagy in the segregation of dysfunctional mitochondria. The …
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