MC4受體，即 MC4R，是在人體中由MC4R基因編碼的 黑素皮质素受體 [7][8][9]。 它編碼MC4蛋白。 在小鼠中，已發現MC4受體參與進食行為，代謝，性行為和男性勃起功能的調節 [10][11][12]。 據2008年的報導，MC4R突變與人類遺傳性肥胖有關 [13]。 在體重指數大於30的人群中，該病的患病率為1.0–2.5％，是最容易導致肥胖的最常見遺傳缺陷。 [來源請求] ^ 與黑素皮质素受体4相關的疾病；在維基數據上查看/編輯參考. ^ 對黑皮质素受体4起作用的藥物；在維基數據上查看/編 …

Mutations in the MC4R are the most common monogenic form of obesity. Functional studies of the mutant MC4Rs and the therapeutic implications, including small molecules acting as pharmacological chaperones in rescuing intracellularly retained mutants, are highlighted. II. Molecular Cloning and Localization of the Melanocortin-4 Receptor. III.

2016年1月27日 · In this regard, the melanocortin-4 receptor is a critical coordinator of mammalian energy homeostasis and body weight. Drawing on recent advances in neuroscience and genetic...

2020年4月24日 · 我校iHuman研究所在肥胖症药物靶点研究上获重要突破，首次解析人源黑皮质素受体4（Melanocortin-4 Receptor，MC4R）与环形多肽配体SHU9119复合物2.8埃分辨率的晶体结构。 该成果以“Determination of theMelanocortin-4 Receptor …

2021年8月25日 · Melanocortin-4 receptor (MC4R) plays a central role in the regulation of energy homeostasis. Its high sequence similarity to other MC receptor family members, low...

Melanocortin 4 receptor (MC4R) is a melanocortin receptor that in humans is encoded by the MC4R gene highly expressed in paraventricular nucleus of the hypothalamus. [5][6][7] It encodes the MC 4 R protein, a G protein-coupled receptor (GPCR) that binds α-melanocyte stimulating hormone (α-MSH).

2024年10月1日 · We solve the active state MC4R structure in complex with the full agonistic nanobody pN162 at 3.4 Å resolution. The structure shows a distinct interaction with pN162 binding deeply in the...

2024年12月25日 · MC4R (Melanocortin 4 Receptor) is a Protein Coding gene. Diseases associated with MC4R include Body Mass Index Quantitative Trait Locus 20 and Obesity Due To Melanocortin 4 Receptor Deficiency. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

The Mitsubishi model designation for this engine was A10 while it was an experimental project, in service it was known as the MK4, and known as the Ha101 & Ha111 by the Army and Kasei by the Navy. According to unified designation code it was Ha-32 of the variants from 11 to 27.

Melanocortin 4 receptor (MC4R) is a G-protein coupled receptor highly expressed in paraventricular nucleus of the hypothalamus and plays an important role in energy homeostasis, eating behavior, adipose tissue formation and satiety.