2021年7月5日 · Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2 (MKI-2) identified in silico through a drug discovery program. Our data showed that MKI-2 inhibited recombinant MASTL activity and cellular MASTL activity with IC 50 values of 37.44 nM and 142.7 nM, respectively, in breast cancer cells.

In the present study, we developed a second-generation MASTL inhibitor MKI-2 using an in silico-based drug discovery program involving a docking model. MKI-2 showed nM range potency and efficacy for MASTL inhibition in breast cancer cells.

2021年7月5日 · In the present study, we developed a second-generation MASTL inhibitor MKI-2 using an in silico-based drug discovery program involving a docking model. MKI-2 showed nM range potency and efficacy for MASTL inhibition in breast cancer cells.

MKI2 2.2/50/20 LS5 – 2.2 µF Film Capacitor Polyphenylene Sulfide (PPS), Metallized Radial from WIMA. Pricing and Availability on millions of electronic components from Digi-Key Electronics.

2021年12月14日 · Here, we show that mouse models of IBD exhibit variable responses to inhibition a MK2, a pro-inflammatory serine/threonine kinase, and that MK2 inhibition suppresses inflammation by targeting inflammatory monocytes and neutrophils.

Our primary outcome was comparison of RR between MKI given before ICI (MKI1) and MKI given after ICI (MKI2). Our secondary outcome was progression-free survival (PFS). Results: Seventeen patients had MKI1, while 11 patients had MKI2, of …

Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2 (MKI-2) identified in silico through a drug disco... ... validate that MKI-2 inhibited MASTL in breast...

Download scientific diagram | The MASTL inhibitor, MKI-2, sensitizes tumors with increased chromosomal instability and downregulation of MASTL-ENSA-Aurora A. A Schematic representation of MKI-2...

Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2 (MKI-2) identified in silico through a drug disco... ... we next examined the antitumor activities of MKI-2...

46 01.10 D WIMA MKI 2 Test voltage: 1.6 U r, 2 sec. Voltage derating: A voltage derating factor of 0.75 % per K must be applied from +125+ C for DC voltages and from +110+ C for AC