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2011年6月1日 · Both MKKs synergistically phosphorylate different JNK isoforms and are therefore involved in numerous physiological (e.g. differentiation and proliferation) and pathological (e.g. apoptosis and tumorigenesis) processes. MKK4 and MKK7 share similar molecular characteristics as well as several upstream activators and scaffold proteins.

2015年3月3日 · MKK7 activates the c-Jun N-terminal kinase (JNK) pathway and is the only MKK containing three motifs within its regulatory domain. Here we obtain a comprehensive picture of the structure, dynamics, affinity, stoichiometry, and kinetics of the MKK7–JNK signaling complex.

Mitogen-activated protein kinases (MAPK) are activated by phosphorylation on Thr and Tyr by MAPK kinases. Two MAPK kinases (MKK4 and MKK7) can activate the c-Jun NH 2 -terminal kinase (JNK) group of MAPK in vitro. JNK is phosphorylated preferentially on …

2002年9月1日 · MLKs are members of mitogen-activated-protein kinase (MAPK) modules that contain c-Jun amino-terminal kinase (JNKs) or p38 MAPKs. MLKs bind the scaffold-like JNK-interacting proteins (JIPs). The...

2019年2月15日 · Find more information on the Altmetric Attention Score and how the score is calculated. The protein kinase MKK7 is linked to neuronal development and the onset of cancer. The field, however, lacks high-quality functional probes that would allow for the dissection of its detailed functions.

2011年2月22日 · 促分裂原活化蛋白激酶（MKK）4和7的功能通常与c-Jun N端激酶（JNK）信号通路相关。 两种MKK协同磷酸化不同的JNK同工型，因此参与许多生理过程（例如分化和增殖）和病理过程（例如凋亡和肿瘤发生）。

The c-Jun NH(2)-terminal protein kinase (JNK) plays important roles in a broad range of physiological processes. JNK is controlled by two upstream regulators, mitogen-activated protein kinase kinase (MKK) 4 and MKK7, which are activated by various MAPKKKs. Studies employing knockout mice have demons …

2019年9月24日 · In this review, we discuss the molecular characterization, activation process, and physiological functions of mitogen-activated protein kinase kinase 7 (MKK7), the MAP2K that most specifically...

2005年6月1日 · MAPKs are members of a three-kinase phosphorelay system composed of the MAPK, MAPK kinase (MKK) and MAPK kinase kinase (MKKK). MKKKs phosphorylate and activate MKKs, which in turn phosphorylate and activate MAPKs. Scaffolding proteins organize MKK–MAPK complexes for activation by specific MKKKs and do so in …