mapk通路有4种主要的分支路线： erk 、 jnk 、 p38 /mapk和erk5。 其中，JNK和p38功能相似，跟炎症、凋亡、生长都有关；ERK主要管细胞生长、分化，其上游信号是著名的 Ras/Raf 蛋白。

2015年3月3日 · MKK7 activates the c-Jun N-terminal kinase (JNK) pathway and is the only MKK containing three motifs within its regulatory domain. Here we obtain a comprehensive picture of the structure, dynamics, affinity, stoichiometry, and kinetics of the MKK7–JNK signaling complex.

The c-Jun NH(2)-terminal protein kinase (JNK) plays important roles in a broad range of physiological processes. JNK is controlled by two upstream regulators, mitogen-activated protein kinase kinase (MKK) 4 and MKK7, which are activated by various MAPKKKs. Studies employing knockout mice have demons …

2011年6月1日 · The central question is how two MKKs regulate or affect the multiple actions of their JNK substrates. Similar to JNKs, MKK4 and MKK7 can simultaneously exert divergent functions in different cellular compartments and signalosomes. It is also important to realize that the MKK effects are splice variant-specific.

JNK/SAPK (c-Jun kinase/stress activated protein kinase)级联反应能被UV辐射、热激或者炎症因子激活。 如下图，举例其中一个途径： 这类MAPK通路可以由两种小G蛋白Rac和Cdc42介导。

JNK又被称为应激活化蛋白激酶（stress-activated protein kinase, SAPK），是哺乳类细胞中MAPK（Mitogen-activated Protein Kinase，丝裂原活化蛋白激酶）信号通路的另一亚类。MAPK-JNK通路可由各种不同环境应激、炎症细胞因子、生长因子以及CPCR激动剂激活。

研究发现，ad患者死后的大脑样本中，磷酸化jnk（p-jnk）水平升高，并且与aβ呈正相关。 JNK会调节淀粉样前体蛋白（APP）的功能和代谢，促使APP快速转运到细胞表面并磷酸化，最终被β - 分泌酶切割产生Aβ。

2011年2月22日 · 促分裂原活化蛋白激酶（MKK）4和7的功能通常与c-Jun N端激酶（JNK）信号通路相关。 两种MKK协同磷酸化不同的JNK同工型，因此参与许多生理过程（例如分化和增殖）和病理过程（例如凋亡和肿瘤发生）。

The functions of mitogen-activated protein kinases (MKKs) 4 and 7 are typically associated with the c-Jun N-terminal kinase (JNK) signaling pathway. Both MKKs synergistically phosphorylate different JNK isoforms and are therefore involved in numerous physiological (e.g. differentiation and …

2001年7月19日 · We find that the TAK1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF6 and Ubc13–Uev1A. Moreover, the activity of TAK1 to phosphorylate MKK6, which activates the...