2017年4月6日 · Here, we show that, during necroptosis, MLKL-dependent calcium (Ca 2+) influx and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded …

Loss of MLKL enhanced intestinal regeneration and the susceptibility to intestinal tumorigenesis in Apcmin/+ mice by hyperactivating the Janus kinase 2 (JAK2)/ signal transducer and activator …

Mixed lineage kinase domain-like (MLKL) protein is the main player of this cell death pathway as it mediates the final step of plasma membrane permeabilization. Despite the significant progress …

2025年2月8日 · These cDAMPs act as “danger signals,” binding to pattern recognition receptors (PRRs) like TLRs and RAGE to promote antigen-presenting cell (APC) activation and …

2021年2月17日 · Loss of MLKL enhanced intestinal regeneration and the susceptibility to intestinal tumorigenesis in Apc min/+ mice by hyperactivating the Janus kinase 2 (JAK2)/ …

2021年2月17日 · MLKL 的缺失通过过度激活 Janus 激酶 2 (JAK2)/信号转导和转录激活因子 3 (STAT3) 轴，增强了Apc min/+小鼠的肠道再生和肠道肿瘤发生的易感性。 此外，MLKL 缺乏会 …

Loss of MLKL enhanced intestinal regeneration and the susceptibility to intestinal tumorigenesis in Apcmin/+ mice by hyperactivating the Janus kinase 2 (JAK2)/ signal transducer and activator …

2023年6月14日 · In this review, we discuss the key steps that lead to MLKL activation, possible models that explain how it becomes the death executor in necroptosis, and its emerging …

2021年2月17日 · Mixed lineage kinase domain-like protein (MLKL) plays an important role in necroptosis, but the role and mechanism of MLKL in intestinal tumorigenesis remain unclear. …

We found that anemia and thymus atrophy were significantly exacerbated in Apc min/+ Mlkl -/-mice compared to Apc min/+ littermate controls, suggesting that loss of MLKL increased …