MLKL overexpression leads to Ca 2+ and metabolic …
2024年5月1日 · Over expression of MLKL leads to both Ca 2+ dyshomeostasis and metabolic remodelling, demonstrating that the activation of the necroptotic pathway in the absence of cell …
The molecular mechanisms of MLKL-dependent and MLKL …
Mixed lineage kinase domain-like pseudokinase (MLKL) is considered to be the key mediator of necroptosis. After necroptosis initiation, MLKL together with RIP1 and RIP3 forms necrosome, …
The Many Faces of MLKL, the Executor of Necroptosis - MDPI
2023年6月14日 · Mixed lineage kinase domain-like (MLKL) protein is the main player of this cell death pathway as it mediates the final step of plasma membrane permeabilization. Despite the …
Cytoplasmic calcium influx mediated by plant MLKLs confers TNL ...
2024年3月20日 · We show that the AtMLKL HeLo domain mediates cytoplasmic Ca 2+ ([Ca 2+] cyt) influx in plant and human cells, and AtMLKLs are responsible for sustained [Ca 2+] cyt …
MLKL forms cation channels | Cell Research - Nature
2016年4月1日 · In this study, we provide direct evidence that MLKL forms transmembrane cation channels. The MLKL channel is permeable to Mg 2+, Na + and K + but not Ca 2+, making it …
Plasma membrane translocation of trimerized MLKL protein is …
Here we show that MLKL forms homotrimers and locates to the cell plasma membrane during TNF-induced necroptosis. Importantly, we found that MLKL membrane localization is critical …
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell …
2017年4月6日 · The activation of mixed lineage kinase-like (MLKL) by receptor-interacting protein kinase-3 (RIPK3) results in plasma membrane (PM) disruption and a form of regulated …
MLKL overexpression leads to Ca - ScienceDirect
2024年5月1日 · MLKL regulates cytosolic Ca 2+ clearance and increases Ca 2+ release from the endoplasmic reticulum in Neuro-2a cells. Transient Ca 2+ elevations in MLKL-overexpressing …
MLKL as an emerging machinery for modulating organelle …
Activated MLKL accumulates on the endoplasmic reticulum and benefits the influx of cation-Ca 2+, leading to calcium overload in the endoplasmic reticulum and ERS (Gong et al., 2017). …
MLKL overexpression leads to Ca - PubMed
We found that MLKL overexpression marginally decreased cell viability, however, it led to reduced cytosolic and mitochondrial Ca 2+ elevations in response to Ca 2+ influx from the extracellular …