MLKL, the Protein that Mediates Necroptosis, Also ... - Cell Press
2017年7月18日 · Activation of the pseudokinase mixed lineage kinase domain-like (MLKL) upon its phosphorylation by the protein kinase RIPK3 triggers necroptosis, a form of programmed …
MLKL trafficking and accumulation at the plasma membrane
2020年6月19日 · Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought...
MLKL in cancer: more than a necroptosis regulator | Cell Death …
2021年5月5日 · Mixed lineage kinase domain-like protein (MLKL) emerged as executioner of necroptosis, a RIPK3-dependent form of regulated necrosis. Cell death evasion is one of the …
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell …
2017年4月6日 · Here, we show that, during necroptosis, MLKL-dependent calcium (Ca 2+) influx and phosphatidylserine (PS) exposure on the outer leaflet of the plasma membrane preceded …
MLKL polymerization-induced lysosomal membrane …
2023年11月23日 · Mixed lineage kinase-like protein (MLKL) forms amyloid-like polymers to promote necroptosis; however, the mechanism through which these polymers trigger cell …
Mixed Lineage Kinase Domain-like Protein MLKL Causes ... - Cell …
Reported here is the development of a monoclonal antibody that specifically recognizes phosphorylated MLKL in cells dying of this pathway and in human liver biopsy samples from …
The molecular mechanisms of MLKL-dependent and MLKL …
Mixed lineage kinase domain-like pseudokinase (MLKL) is considered to be the key mediator of necroptosis. After necroptosis initiation, MLKL together with RIP1 and RIP3 forms necrosome, …
Mol Cell：程序性细胞坏死执法方式：MLKL引发细胞膜完整性破坏 …
这些研究结果以Molecular Cell杂志封面发表，这篇文章同时介绍了王晓东实验室和Epitomics公司的科学家合作开发的能特异识别人源MLKL磷酸化的单克隆抗体，并证明这一磷酸化抗体可作 …
孙丽明组合作发现细胞坏死执行蛋白MLKL的抑制性磷酸化修饰阻 …
2022年2月23日 · 2021年11月2日，国际学术期刊Cell Research在线发表了中国科学院分子细胞科学卓越创新中心（生物化学与细胞生物学研究所）孙丽明研究组与上海科技大学生命科学与技 …
MLKL: Functions beyond serving as the Executioner of Necroptosis
2022年3月1日 · In this review, we briefly introduce the current state of knowledge regarding the structure of MLKL, necroptosis signaling, as well as cross-linkages among necroptosis and …