
Mlkl knockout mice demonstrate the indispensable role of Mlkl in ...
2013年7月9日 · Mlkl deficiency protects mice from cerulean-induced acute pancreatitis, a necrosis-related disease, but has no effect on polymicrobial septic shock-induced animal …
A RIPK3-independent role of MLKL in suppressing parthanatos
2023年1月17日 · Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a …
037116 - MLKL KO Strain Details - The Jackson Laboratory
037116 C57BL/6- Mlkl em1Hmni /J Mlkl knock-out mice have exon 2 of the Mlkl (mixed lineage kinase domain-like) locus disrupted. Mice homozygous for the mutation are less susceptible to …
Translocation of mixed lineage kinase domain-like protein to …
2013年12月24日 · Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis...
【小优细节君】坏死性凋亡之MLKL检测经验分享 - 知乎
mlkl是tnf(肿瘤坏死因子)诱导的坏死性凋亡过程中的关键靶标,它作为ripk1和ripk3下游的效应蛋白发挥作用。 RIPK3在Ser227位点被磷酸化,此磷酸化为MLKL激活所必需。
Mlkl-KO - 南模生物
通过敲除Mlkl基因的exon 3-5建立Mlkl基因敲除小鼠模型。 *使用本品系发表的文献需注明: Mlkl-KO mice (Cat. NO. NM-KO-220338) were purchased from Shanghai Model Organisms Center, …
MLKL 缺乏通过激活线粒体自噬抑制肝缺血和再灌注损伤期间的巨 …
MLKL 敲除 (KO) 减轻了肝脏 IR 损伤并抑制了肝内巨噬细胞中 cGAS-STING 信号的激活,这被 STING 及其激动剂激活所消除。 从机制上讲,IR 在肝细胞中诱导氧化性 DNA 损伤,导致巨噬 …
Mlkl基因敲除小鼠_构建_价格_策略_48小时发货-赛业生物
Mlkl位于小鼠的8号染色体,采用基因编辑技术,通过应用高通量电转受精卵方式,获得Mlkl基因敲除小鼠,性成熟后取精子冻存。 Mlkl-KO小鼠模型由赛业生物(Cyagen)采用基因编辑技术 …
Mixed Lineage Kinase Domain-like Protein MLKL Causes ... - Cell …
2014年4月10日 · MLKL is a pseudokinase that is able to bind RIP3 through its kinase-like domain, and cells from MLKL knockout mice demonstrate resistance to necroptosis similar to that from …
ZBP1-MLKL necroptotic signaling potentiates radiation-induced …
2021年10月6日 · In this study, we found that the ZBP1-MLKL necroptotic signaling cascade governs antitumor immune responses after radiation by mutually interacting with STING …