2013年7月9日 · Mlkl deficiency protects mice from cerulean-induced acute pancreatitis, a necrosis-related disease, but has no effect on polymicrobial septic shock-induced animal …

2023年1月17日 · Mixed lineage kinase domain-like (MLKL) is widely accepted as an executioner of necroptosis, in which MLKL mediates necroptotic signaling and triggers cell death in a …

037116 C57BL/6- Mlkl em1Hmni /J Mlkl knock-out mice have exon 2 of the Mlkl (mixed lineage kinase domain-like) locus disrupted. Mice homozygous for the mutation are less susceptible to …

2013年12月24日 · Mixed lineage kinase domain-like protein (MLKL) was identified to function downstream of receptor interacting protein 3 (RIP3) in tumor necrosis...

mlkl是tnf（肿瘤坏死因子）诱导的坏死性凋亡过程中的关键靶标，它作为ripk1和ripk3下游的效应蛋白发挥作用。 RIPK3在Ser227位点被磷酸化，此磷酸化为MLKL激活所必需。

通过敲除Mlkl基因的exon 3-5建立Mlkl基因敲除小鼠模型。 *使用本品系发表的文献需注明: Mlkl-KO mice (Cat. NO. NM-KO-220338) were purchased from Shanghai Model Organisms Center, …

MLKL 敲除 (KO) 减轻了肝脏 IR 损伤并抑制了肝内巨噬细胞中 cGAS-STING 信号的激活，这被 STING 及其激动剂激活所消除。 从机制上讲，IR 在肝细胞中诱导氧化性 DNA 损伤，导致巨噬 …

Mlkl位于小鼠的8号染色体，采用基因编辑技术，通过应用高通量电转受精卵方式，获得Mlkl基因敲除小鼠，性成熟后取精子冻存。 Mlkl-KO小鼠模型由赛业生物（Cyagen）采用基因编辑技术 …

2014年4月10日 · MLKL is a pseudokinase that is able to bind RIP3 through its kinase-like domain, and cells from MLKL knockout mice demonstrate resistance to necroptosis similar to that from …

2021年10月6日 · In this study, we found that the ZBP1-MLKL necroptotic signaling cascade governs antitumor immune responses after radiation by mutually interacting with STING …