Necrosulfonamide | Necroptosis 抑制剂 | MCE - MCE-生物活性分 …
Necrosulfonamide is a necroptosis inhibitor acting by selectively targeting the mixed lineage kinase domain-like protein (MLKL). Necrosulfonamide prevents MLKL-RIP1-RIP3 necrosome …
MLKL polymerization-induced lysosomal membrane …
2023年11月23日 · The MLKL inhibitor necrosulfonamide (NSA) which inhibits MLKL polymerization was found to block MLKL colocalization with the lysosome, suggesting a …
Necrosulfonamide exerts neuroprotective effect by inhibiting ...
2023年5月31日 · Necrosulfonamide (NSA) is a specific MLKL inhibitor that suppresses necroptosis 9. Recent studies have shown that NSA has a therapeutic window in rodent …
MLKL trafficking and accumulation at the plasma membrane
2020年6月19日 · Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. RIPK3-mediated phosphorylation is thought...
Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic …
2014年4月10日 · Necroptosis can be specifically inhibited by RIP1 inhibitor necrostatin-1 (Nec-1) and MLKL inhibitor necrosulfonamide (NSA), which targets the N-terminal coiled-coil domain …
MLKL forms disulfide bond-dependent amyloid-like polymers to ... - PNAS
2017年8月21日 · We examined the effect of NSA on MLKL polymer formation. As shown in Fig. 6A, NSA inhibited recombinant NTD polymerization in vitro in a dose-dependent manner …
Locking mixed-lineage kinase domain-like protein in its auto …
2020年12月14日 · Two covalent inhibitor classes targeting the same cysteine of the necroptosis effector protein mixed-lineage kinase domain-like protein (MLKL) are reported. Here, we …
Identification of MLKL membrane translocation as a checkpoint in ...
2020年3月31日 · We identified monobodies that inhibit necroptotic signaling by binding to an indispensable site on the α4 helix of human MLKL’s N-terminal four-helix bundle “killer” …
The brain protection of MLKL inhibitor necrosulfonamide against …
2023年10月24日 · In a transient middle cerebral artery occlusion (tMCAO) rat model in vivo, and an oxygen-glucose deprivation and reoxygenation (OGD/Re) injury model in both primary …
美国APExBIO中文官网 - Necrosulfonamide
Necrosulfonamide（NSA）是混合谱系激酶样蛋白（MLKL）的药理学抑制剂[1]。 NSA可以有效防止人类HT-29的坏死性死亡，IC50值为124 nM [2]。 MLKL是功能性RIP3的底物，可以通过其 …
- 某些结果已被删除