Malonyl-CoA decarboxylase (EC 4.1.1.9), (which can also be called MCD and malonyl-CoA carboxyl-lyase) is found in bacteria and humans and has important roles in regulating fatty acid metabolism and food intake, and it is an attractive target for drug discovery. It is an enzyme associated with Malonyl-CoA decarboxylase deficiency.

2024年12月25日 · MLYCD (Malonyl-CoA Decarboxylase) is a Protein Coding gene. Diseases associated with MLYCD include Malonyl-Coa Decarboxylase Deficiency and Lipid Metabolism Disorder. Among its related pathways are Peroxisomal lipid metabolism and Metabolism.

丙二酰辅酶A脱羧酶 （英語： Malonyl-CoA decarboxylase，又称为 丙二酸单酰辅酶A脱羧酶）是一个与 丙二酰辅酶A脱羧酶缺乏症 相关的酶。 这种酶催化 丙二酰辅酶A 转变为 乙酰辅酶A 与 二氧化碳。 在一定程度上说，这种酶是 乙酰辅酶A羧化酶 的逆反应酶。

The MLYCD gene provides instructions for making an enzyme called malonyl-CoA decarboxylase. This enzyme helps regulate the formation and breakdown of a group of fats called fatty acids.

该基因的产物催化丙二酰辅酶 A 分解为乙酰辅酶 A 和二氧化碳。 丙二酰辅酶 A 是脂肪酸生物合成的中间体，也抑制脂酰辅酶 A 向线粒体的转运。 因此，编码的蛋白质起到增加脂肪酸氧化速率的作用。 它存在于线粒体、过氧化物酶体和细胞质中。 该基因的突变导致丙二酰辅酶 A 脱羧酶缺乏症。 [RefSeq 提供，2008 年 7 月] The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide.

2023年12月1日 · Malonyl-CoA decarboxylase deficiency (MLYCDD) is an ultra-rare inherited metabolic disorder, characterized by multi-organ involvement manifesting during the first few months of life. Our aim was to describe the clinical, biochemical, and genetic characteristics of patients with later-onset MLYCDD.

2023年12月1日 · Here, we identified that malonyl-CoA decarboxylase (MLYCD), a key regulator of fatty acid anabolism, was downregulated in ccRCC, and low expression correlated with poor prognosis in patients. Restoring MLYCD expression in ccRCC cells decreased the content of malonyl CoA, which blocked de novo fatty acid synthesis and promoted fatty acid ...

2025年2月8日 · The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. Structural asymmetry and disulfide bridges among subunits modulate the activity of human malonyl-CoA decarboxylase.

2024年8月27日 · The MLYCD catalytic domain is structurally homologous to those of the GCN5-related N-acetyltransferase superfamily. Title: Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

2024年9月12日 · Clinical resource with information about MLYCD, Deficiency of malonyl-CoA decarboxylase, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.