Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle.

Mmae | C39H67N5O7 | CID 21976333 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells.

耦合到cac10时，mmae在cd30 + 细胞中表现出选择性细胞毒性，并通过诱导细胞凋亡，引起g2/m期生长阻滞和细胞死亡。 在体外，与抗-cd79b抗体耦合时，抗-cd79b-vcmmae对一大组nhl细胞系具有非常有效且广泛的活性。

MOL SDF PDB SMILES InChI. Similar Structures. Structure for Monomethyl Auristatin E (MMAE) ... Monomethyl Auristatin E (MMAE) Spectra. Spectrum Spectrum Type Splash Key; Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS: splash10-0wmi-0333221900-0030a6931947a964d106:

Monomethyl auristatin E (MMAE; SGD-1010) 是海兔毒素 10 的合成衍生物，通过抑制微管蛋白聚合而起到有效的有丝分裂抑制作用。 MMAE 广泛用作细胞毒性成分制作抗体偶联活性分子 (ADCs) 用于癌症的研究。

2023年11月9日 · 缔码生物开发了适合ADC ELISA 测定的anti-MMAE抗体，它可用于定量测定测试样品中anti-MMAE-缀合物的水平， 可用于PK检测以及DAR值分析，加速ADC药物的研发进程。

Monomethyl auristatin E (MMAE; SGD-1010) 是海兔毒素10的合成衍生物，通过抑制微管蛋白 (tubulin) 聚合而起到有效的有丝分裂 (mitotic) 抑制作用。 MMAE广泛用作细胞毒性成分制作抗体-药物偶联物 (ADCs) 以治疗癌症。

2011年7月16日 · 方法:将Her2抗体通过一个可降解的linker与小分子毒素(MMAE)连接起来,形成抗体药物偶联物(ADC)。 通过细胞学试验检测Her2抗体-MMAE偶联物对于肿瘤细胞抑制、细胞凋亡和细胞周期的作用。

Monomethyl auristatin E (MMAE) is efficiently released from SGN-35 within CD30 + cancer cells and, due to its membrane permeability, is able to exert cytotoxic activity on bystander cells. MMAE sensitizes colorectal and pancreatic cancer cells to IR in a schedule and