The structure of dolastatin 10 was used as the basis for derivatives monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF), both of which possess an N-terminal …

2022年11月3日 · Monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are identified as the best analogs of dolastatin 10, which bind to microtubules and prevent cell …

A simple and highly sensitive workflow is developed and validated for the simultaneous quantification of six ADC payloads, namely SN-38, MTX, DXd, MMAE, MMAF and …

当前上市的ADC 采用的细胞毒素按作用机制可分为两大类：即 微管蛋白抑制剂 和 DNA损伤剂，具体如下表所示： 1、微管蛋白抑制剂类payload. 1）MMAE. MMAE是一种高效细胞毒素，通过 …

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. [1] It is part of the approved drug belantamab mafodotin in multiple myeloma and some experimental anti-cancer antibody …

A simple liquid chromatography–quadrupole-time-of-flight–mass spectrometric assay (LC-TOF-MS/MS) has been developed for the evaluation of metabolism and pharmacokinetic (PK) …

2016年3月30日 · Here we describe the high resolution structures of tubulin in complex with both monomethyl auristatin E and F and unambiguously define the trans-configuration of both …

In this review, we elucidate the definition of MMAF from a systematical view, the difference between MMAF and other conditions with asthenoteratozoospermia or asthenozoospermia …

The structure of dolastatin 10 was used as the basis for derivatives monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF), both of which possess an N-terminal …

2023年6月26日 · Multiple morphological abnormalities of the sperm flagella (MMAF) constitute one of the most severe forms of sperm defects critical for male infertility and are characterized …