MMP-20, also known as enamelysin, appears to be the only MMP that is tooth-specific and it is expressed by cells of different developmental origin (i.e. epithelial ameloblasts and mesenchymal odontoblasts).

2024年12月25日 · MMP20 (Matrix Metallopeptidase 20) is a Protein Coding gene. Diseases associated with MMP20 include Amelogenesis Imperfecta, Hypomaturation Type, Iia2 and Hypomaturation Amelogenesis Imperfecta. Among its related pathways are Collagen chain trimerization and Matrix metalloproteinases.

基质金属蛋白酶（MMPs），1962年首先被确定为一种胶原蛋白水解酶，在蝌蚪尾巴的吸收过程中导致ECM蛋白降解。 属于metzincins超家族，是一类锌依赖性内肽酶，可降解ECM的各种蛋白质组分。 (一) MMP家族结构特点. 在脊椎动物中，MMP家族由28个成员组成，至少23个在人体组织中表达，其中14个在脉管系统中表达。 基质金属蛋白酶通常根据其底物和其结构域的组织结构分为胶原酶（collagenases）、明胶酶（gelatinases）、溶血素（stromelysins）、基质溶 …

Novel homozygous mutation MMP20 (c.1054G>A, p.Glu352Lys) genes were identified in amelogenesis imperfect consanguinity. Mutant MMP20 was expressed at a normal level but secreted only minimally with proteolytic function.

2016年7月11日 · Matrix metalloproteinase-20 (MMP20) is expressed by ameloblasts in developing teeth and MMP20 mutations cause enamel malformation. We established a stably transfected Tet -Off Mmp20...

基质金属蛋白酶 (MMP) 家族的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。 大多数 MMP's 被分泌为无活性的前蛋白，当被细胞外蛋白酶切割时被激活。 由该基因编码的蛋白质降解牙釉质基质的主要蛋白质成分牙釉质，因此被认为在牙釉质形成中发挥作用。 该基因的突变会改变正常的剪接模式并导致编码蛋白质的过早终止，与釉质发育不全症有关。 该基因是位于染色体 11q22.3 上的 MMP 基因簇的一部分。 …

2007年5月1日 · Matrix metalloproteinase-20 (MMP20; enamelysin) is important for proteolytic processing of extracellular matrix (ECM) proteins during the formation of enamel and plays a critical role in proteolytic processing of amelogenin (AMEL), the …

2021年4月4日 · Significantly high expression levels of MMP20 and DSPP were observed in the malignant breast, colon, prostate, thyroid, and cervical neoplasms compared with their benign and normal counterparts. Furthermore, MMP20 levels increased with …

Matrix metallopeptidase 20 (MMP20) is an evolutionarily conserved protease that is essential for processing enamel matrix proteins during dental enamel formation. MMP20 mutations cause human autosomal recessive pigmented hypomaturation‐type ...

Ameloblasts responsible for enamel formation express matrix metalloproteinase 20 (MMP20), an enzyme that cleaves enamel matrix proteins, including amelogenin (AMELX) and ameloblastin (AMBN). Previously, we showed that continuously erupting incisors from transgenic mice overexpressing active MMP20 ha …