Discovery of Potent and Selective MNK Kinase Inhibitors for the ...
2025年3月4日 · MNK activity is regulated by the p38 and Erk MAPK pathways. Phosphorylation of MNK leads to its activation and binding to the eIF4G/eIF4E complex. MNK then …
MNK, mTOR or eIF4E-selecting the best anti-tumor target for …
2023年11月15日 · To explore the optimal anti-cancer targets among MNK, mTOR, and eIF4E, this review provides a detailed classification and description of the anti-cancer activities of …
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven
2014年11月18日 · We propose that MNKs can modulate oncogenic translation by regulating eIF4E1-eIF4E3 levels and activity in DLBCL. There are multiple aetiologies to cancer …
The MNK-1/eIF4E pathway as a new therapeutic pathway to …
Here we present data that inhibition of MAPK-activated protein kinase (MNK)-1 reduces inflammation and remodelling. MNK-1 regulates protein expression by controlling mRNA …
MNK、mTOR 或 eIF4E——选择阻断翻译起始的最佳抗肿瘤靶 …
为了探索 MNK、mTOR 和 eIF4E 之间的最佳抗癌靶点，本综述对有前景的化合物的抗癌活性进行了详细的分类和描述。 此外，还简要描述了一些双靶点抑制剂的结构和活性。 通过分析抑制 …
Mnk earmarks eIF4E for cancer therapy - PMC
The phosphorylation of eIF4E by Mnk1/2 provides a new avenue for cancer therapy. The inhibition of eIF4E phosphorylation could have similar consequences as the inhibition mTORC1 by …
MNK-driven eIF4E phosphorylation regulates the fibrogenic ...
2024年8月15日 · We delineate a unique JNK/MNK/eIF4E signaling axis in fibrotic MCs with an interesting and surprising finding that JNK is the primary kinase upstream of constitutively …
9HRC: Structure of MNK2 in complex with inhibitor NUCC …
2024年12月17日 · MNK then phosphorylates eIF4E at Ser209, whose activation is associated with oncogene translation, leading to tumorigenesis. Given this important role for eIF4E in …
The Akt/mTOR and MNK/eIF4E pathways rewire the prostate …
Among different secreted proteins released by prostate tumor cells, we identified Hgf, Spp1, and Bgn as the key factors that regulate MDSCs migration. Mechanistically, we found that the …
Targeting translation: eIF4E as an emerging anticancer drug target
2016年1月18日 · Mnk-induced eIF4E phosphorylation is closely related to mTOR pathway inhibition (Refs Reference Shi 145, Reference Wang 146). Two research groups have …