2023年7月4日 · Type 2 Modic Changes. Type 2 changes are more common and represent a more chronic state. When you see Type 2 changes on an MRI scan, it means there’s decreased signal intensity, suggesting a fatty degeneration or replacement of the normal bone marrow.

2024年5月7日 · Modic type endplate changes represent a classification for vertebral body endplate MRI signal changes, first described in 1988 1. It is widely recognized by radiologists and clinicians and is a useful shorthand for reporting MRIs of the spine.

Type 2 classifies subacute and chronic changes as fatty bone marrow infiltration occurs within the vertebral body with the MRI demonstrating hyperintense signals on both T1 and T2 weighted images. The progression of chronic changes may lead to bony sclerosis at the endplates, observed within the Type 3 Modic classification.

2025年3月12日 · Explore the significance of Modic Type 2 endplate changes, their radiological features, and potential links to spinal health and lumbar conditions. Changes in the spinal endplates can significantly impact back health, particularly when involving Modic Type 2 lesions.

腰椎终板及终板下骨质在MRI上的信号改变被称为Modic改变，其发生率正常人群中为6%，腰背痛人群中为40%，Modic改变在中年会进展，而且具有一定的遗传易感性。 伴有Modic改变更容易影响腰痛患者的工作和生活。 因此Modic. 椎体软骨终板分为骨性终板和软骨终板，其作用非常重要，对维持脊柱的整体以及椎间盘的功能有重要的意义，研究表明终板的生物力学和生物化学特性的改变容易引起椎间盘退变相关疾病。 腰椎终板及终板下骨质在MRI上的信号改变被称为Modic …

Modic type 2 changes (MC2) are fibroinflammatory changes with complement system involvement which occur adjacent to damaged endplates. Endplate degeneration correlates with complement and neurogenic proteins, which suggests that complement system activation and neoinnervation may be linked to endplate injuries.

Modic changes are a non-specific pathoanatomical marker observed on an MRI scan. For example, high blood pressure or high body temperature can be markers of several diseases. In 2008 the first hypothesis suggesting three possible pathogenetic reasons for Modic changes was published, a bacterial, a mechanical, and a rheumatological cause. [1]

2020年12月11日 · 首次提出最常见的II型Modic改变不仅仅是脂肪化，内部可能还存在着炎症反应、水肿等多种病理形式。 Modic I 型 (a–c)：炎症期或水肿期，俗称为终板炎。 T1低信号，T2高信号。 其病理意义是正常的造血骨髓被纤维血管骨髓所替代。 Modic II型 (d-f)：脂肪期。 T1高信号，T2等信号或高信号。 其病理意义是正常的造血骨髓被脂肪骨髓所替代。 Modic III型 (g-i)：骨质硬化期。 T1WI及T2WI均为低信号。 其病理意义是正常造血骨髓被硬化骨所替代。 图. Ⅱ …

Modic type 2 changes are hyperintense on T1WI (A) and isointense or hyperintense on T2WI (B).

2018年10月23日 · 1988年Modic等[2]系统描述了在退变的腰椎间盘终板及终板下骨质MRI信号改变的类型、分型标准及组织学变化。 近年来，随着MRI在腰椎退变性疾病诊断中的广泛应用,广大学者将腰椎间盘退变性疾病( degenerative disc diseases,DDD)中终板及终板下骨质MRI信号的改变皆称 …