MODY 1 or HNF4A-MODY is a form of maturity onset diabetes of the young. MODY 1 is due to a loss-of-function mutation in the HNF4A (MODY1) gene on chromosome 12. This gene codes for hepatocyte nuclear factor 4-alpha (HNF4-α) protein also known as …

2023年8月14日 · Maturity-onset diabetes of the young (MODY) is a type of monogenic diabetes first described as a mild and asymptomatic form of diabetes that was observed in non-obese children, adolescents, and young adults. Improvement in blood glucose levels has been observed with sulfonylurea treatment.

2018年5月24日 · Maturity-onset diabetes of the young (MODY) is a group of inherited disorders of non-autoimmune diabetes mellitus which usually present in adolescence or young adulthood. A clinical diagnosis of MODY can be suspected in individuals with:

Maturity-onset diabetes of the young (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. [1] Along with neonatal diabetes, MODY is a form of the conditions known as monogenic diabetes.

Maturity-onset diabetes of the young (MODY) is an unusual form of diabetes with specific features that distinguish it from type 1 and type 2 diabetes. There are 14 known subtypes of MODY, and mutations in three genes (HNF1A, HNF4A, GCK) account for about 95% of all MODY cases.

Maturity-onset diabetes of the young (MODY) is a group of monogenic disorders characterized by autosomal dominantly inherited non-insulin dependent form of diabetes classically presenting in adolescence or young adults before the age of 25 years. …

青少年起病的成人型糖尿病（maturity onset diabetes of the young，MODY）是一类特殊类型糖尿病，于1975年首先被报道，通常起病年龄较轻，临床症状不重，有家族遗传史 [1] 。

脆性糖尿病其实是一种较为罕见的形式，其特征是低血糖/高血糖症的频繁发作或严重发作。 因为血糖的各种不稳定性，导致经常住院治疗。 他们需要频繁的自我血糖监测，使用 胰岛素泵 或者使用血糖监测设备（动态CGM）监控血糖的走向。 在极少数情况下，可能需要进行 胰腺移植。 （1） 胰腺移植。 （1） 脆性糖尿病主要出现在1型糖尿病患者中，最常见于20多岁和30多岁的女性，但也可能发生在男性的任何年龄里。 脆性出现的概率大概在3/1000（1） 可能导致脆性糖 …

2021年12月3日 · Maturity Onset Diabetes of the Young (MODY) encompasses a group of rare monogenic forms of diabetes distinct in etiology and clinical presentation from the more common forms of Type 1 (autoimmune) and Type 2 diabetes.

2016年11月30日 · 青少年发病的成人型糖尿病 / 成人起病的青少年糖尿病（Maturity-Onset Diabetes of the Young，MODY）是在 1960 年提出的一种常染色体显性遗传的单基因遗传病，以往认为它是 2 型糖尿病的特殊亚型, 现将之归为特殊类型的糖尿病。 其共同特征包括存在非酮症糖尿病、常染色体显性遗传模式、胰岛 β 细胞功能缺陷。 在欧洲，MODY 占总糖尿病人群的 1%～2%，发病率不是很高，但是具有高度遗传性，MODY 家系中携带突变基因的健康成员的 …