2025年2月12日 · Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) represents a group of inflammatory demyelinating disorders united by the presence of IgG antibodies to myelin oligodendrocyte

2025年1月21日 · MOG antibody disease (MOGAD) is a neurological, immune-mediated disorder in which there is inflammation in the optic nerve, spinal cord and/or brain. Myelin oligodendrocyte glycoprotein (MOG) is a protein that is located on the surface of myelin sheaths in the central nervous system.

Myelin Oligodendrocyte Glycoprotein (MOG) Optic Neuritis is an antibody mediated demyelinating disease of the central nervous system (CNS) that is a distinct entity from other demyelinating processes of the CNS such as Multiple Sclerosis (MS) or AQP4-Ab-associated neuromyelitis optica spectrum disorder (NMOSD). [2] .

Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system (CNS). In humans this protein is encoded by the MOG gene .

MOG antibody disease has a characteristic pattern of brain involvement. It stands unique against MS and NMOSD. Acute disseminated encephalomyelitis is one of the most common presentations especially in patients with younger age at onset. Brain MRI show unique features that could warrant antibody testing as early as the first clinical attack.

2024年11月15日 · 髓鞘少突胶质细胞糖蛋白抗体相关疾病 (myelin oligodendrocyte glycoprotein antibody-associated disease, MOGAD)是一种CNS炎症性疾病，特征为免疫介导的脱髓鞘发作，主要累及视神经、脑和脊髓，好发于儿童。 本文将总结MOGAD的流行病学、发病机制、临床表现和诊断，治疗和预后参见其他专题。 (参见 “髓鞘少突胶质细胞糖蛋白抗体相关疾病的治疗和预后”) 髓鞘少突胶质细胞糖蛋白 (myelin oligodendrocyte glycoprotein, MOG)存在于少突胶质细胞表 …

Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis and aquaporin-4-seropositive neuromyelitis optica spectrum disorder.

MOG (myelin oligodendrocyte glycoprotein) antibody disease (MOGAD) or MOG antibody-associated encephalomyelitis (MOG-EM) [1] is an inflammatory demyelinating disease of the central nervous system.

Myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently identified autoimmune disorder that presents in both adults and children as CNS demyelination.

In this paper, we propose indications for MOG-IgG testing based on expert consensus. In addition, we give a list of conditions atypical for MOG-EM ("red flags") that should prompt physicians to challenge a positive MOG-IgG test result. Finally, we provide recommendations regarding assay methodology, specimen sampling, and data interpretation.