2017年10月20日 · Here we will review how MOMP proceeds and how the main effectors cytochrome c, a heme protein that has a crucial role in respiration, and second mitochondria-derived activator of caspase (SMAC),...

Mitochondrial outer membrane permeabilization (MOMP), also known as the mitochondrial outer membrane permeability, is one of two ways apoptosis (a type of programmed cell death) can be activated. [1] It is part of the intrinsic pathway of apoptosis, also known as the mitochondrial pathway. MOMP is known as the point of no return in apoptosis.

2023年10月11日 · Here we find that MOMP occurring in a subset of mitochondria is a feature of cellular senescence. This process, called minority MOMP (miMOMP), requires BAX and BAK macropores enabling the...

2006年5月19日 · MOMP is directly governed by a subset of the BCL-2 family of proapoptotic proteins, which induce disruptions in the outer mitochondrial membrane (OMM) and subsequent release of death-promoting...

MOMP regulates apoptosis and other forms of cell death. The severity of MOMP varies: miMOMP allows for survival, while completed MOMP causes cell death. Sublethal MOMP can lead to senescence, drug resistance, and genomic instability.

The structural gene for the major outer membrane protein (MOMP) from Chlamydia trachomatis was cloned and sequenced. A lambda gt11 recombinant (lambda gt11/L2/33) that contains a portion of the MOMP coding sequence was used to probe a lambda 1059 library constructed from DNA obtained from C. trachom …

2015年3月5日 · During apoptosis, mitochondrial outer membrane permeabilization (MOMP) is widespread, leading to rapid cell death. Here, Ichim et al. demonstrate that MOMP can also be engaged in a minority of mitochondria without killing the cell.

2015年4月16日 · A key event during apoptosis is mitochondrial outer membrane permeabilization (MOMP), which is regulated by the Bcl-2 family proteins. MOMP results in the release of a number of proteins from the mitochondrial intermembrane space.

Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway and essential to control the execution of cell death. Here we review current concepts in regulation of MOMP focusing on the interaction network of the Bcl-2 family proteins as well as further regulatory elements influencing MOMP.

2010年8月4日 · Mitochondrial outer membrane permeabilization (MOMP) is a crucial event for most apoptotic pathways. MOMP leads to the release of mitochondrial...