TIM-3（T细胞免疫球蛋白粘蛋白-3，又称 CD366 、HAVCR2）是一种 负调控的免疫检查点蛋白。 表达于CD4+T细胞亚群（Th1/Th17细胞）调节性T细胞 (Tregs)、 CD8+T细胞 亚群 (Tc1)以及天然免疫细胞（DC、NK 细胞、单核细胞和巨噬细胞） TIM-3配体. TIM-3有多个配体，如 半乳糖凝集素9 （Galectin-9，主要配体）、癌胚抗原细胞粘附分子1（CEACAM-1）、 高迁移率族蛋白B1 （HMGB1）、 磷脂酰丝氨酸 （PtdSer）。 TIM-3的主要作用是抑制T细胞的活化、增殖，减 …

Studies have shown that TIM-3 plays an important role in autoimmune diseases, chronic viral infections and tumors. A large amount of experimental data supports TIM-3 as an immune checkpoint, and targeting TIM-3 is a promising treatment method in current immunotherapy, especially the new combination of other immune checkpoint blockers.

2022年3月2日 · Conditional deletion of Tim-3 in CD4 T cells and systemic Tim-3 deletion both reduced mortality in response to sepsis in mice by preserving organ function. Tim-3 + CD4 T cells exhibited reduced proliferative ability and elevated expression of inhibitory markers compared with Tim-3 - CD4 T cells.

T cell Ig and mucin domain protein 3 (Tim-3) on the monocytes has been reported to promote immune homeostasis during sepsis, but the influences of plasm soluble Tim-3 (sTim-3) on the immune system during sepsis remain unknown.

TIM3是一类T细胞表面抑制性分子，能够引起癌症与慢性病毒感染过程中T细胞的耗竭。 与 CTLA4， PD1 类似，它也是目前研究最多的免疫治疗的靶点之一。 TIM3作为一种负调控的免疫检查点，于2002年首次被发现，由281个氨基酸组成，并且由一个胞外区、一个单跨膜结构域和一个C-末端细胞质尾部组成。 TIM3选择性地表达在分泌 IFN-γ 的辅助性T细胞 (Th1 和 Th17) 、调节性T细胞 (Treg) 、树突状细胞 (DCs) 、单核细胞、肥大细胞、 NK细胞 、肿瘤浸润淋巴细胞 …

We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3.

2022年3月2日 · Here, using an RNA sequencing assay, we found that the expression of T cell-containing immunoglobulin and mucin domain-3 (Tim-3) on CD4 T cells in sepsis-induced immunosuppression patients was significantly elevated.

2021年10月1日 · TIM-3 is highly expressed on chronic virus-infected T cells. TIM-3 interacts with immune cells and exhibits proliferation or inhibition of tumor cells.

2018年11月22日 · We aim to investigate the effects of Tim-3 and programmed cell death-1 (PD-1) on the monocytes and T lymphocytes in septic patients. Expression of Tim-3 and PD-1 on the CD3, CD4, and CD8 lymphocytes and monocytes was determined using flow cytometry.

TIM-3 has emerged as a promising immune check-point for cancer immunotherapy. It is expressed on various immune cells, such as T cells, natural killer (NK) cells, monocytes, and dendritic cells (DCs), and also on tumor cells, and is involved not …