Mixed-phenotype acute leukemia (MPAL) comprises a heterogenous group of leukemias that are genetically, immunophenotypically, and clinically, diverse. Given the rarity of the disease, the diagnosis and treatment of MPAL is extremely challenging. ...

2022年3月15日 · Mixed-phenotype acute leukemia (MPAL) is a rare type of blood cancer. Typically, a doctor can classify the cancer as acute myeloid leukemia (AML) or acute lymphoblastic...

急性混合细胞白血病（mpal）是一种比较罕见的高危白血病，可能起源于多功能造血干细胞。目前mpal发病机制尚不明确，主要依靠免疫表型分析和分子遗传学诊断。

2015年4月16日 · In adult patients, MPAL is characterized by relative therapeutic resistance that may be attributed in part to the high proportion of patients with adverse cytogenetic abnormalities. No prospective, controlled trials exist to guide therapy.

混合表型急性白血病(mpal)是急性白血病(al)的一种罕见类型，该病患者的白血病细胞可同时表达髓系、t/b细胞系的多种细胞系表型。目前，mpal的诊断主要依据2016年世界卫生组织(who)发布的髓系肿瘤及白血病分类及诊断标准。

混合表型急性白血病(mixed phenotype acute leukemia, MPAL)是指抗原表达模式不明(即反映多个造血谱系)、无法明确归为某一谱系的急性白血病。 根据WHO的定义，MPAL包括以前称为双系列白血病和双表型急性白血病的类型[ 1 ]。

2024年11月5日 · MPAL is a rare and heterogenous subtype of acute leukemia characterized by a single blast population with phenotypic expression of both myeloid and lymphoid lineages (biphenotypic) or multiple co-existing lineages of blasts that satisfy criteria for both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

2024年7月12日 · Mixed phenotype acute leukemia (MPAL) refers to acute leukemias that cannot be unequivocally assigned to one hematopoietic lineage because the malignant blasts express both myeloid and lymphoid antigens. MPAL has previously been described as bilineage leukemia and biphenotypic acute leukemia.

2024年11月5日 · MPAL is a rare and heterogenous subtype of acute leukemia characterized by a single blast population with phenotypic expression of both myeloid and lymphoid lineages (biphenotypic) or multiple co-existing lineages of blasts that satisfy criteria for both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

2018年7月10日 · Nature Communications - Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show...