Mar 15, 2022 · Mixed-phenotype acute leukemia (MPAL) is a rare type of blood cancer. Typically, a doctor can classify the cancer as acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL), depending...

Mixed-phenotype acute leukemia (MPAL) comprises a heterogenous group of leukemias that are genetically, immunophenotypically, and clinically, diverse. Given the rarity of the disease, the diagnosis and treatment of MPAL is extremely challenging. ...

Mar 14, 2023 · Keep reading to learn more about MPAL, its symptoms, and how it’s diagnosed and treated. We also cover the outlook for people with MPAL and whether this type of leukemia is curable.

Mixed-phenotype acute leukemia (MPAL) is a group of blood cancers which have combined features of myeloid and lymphoid cancers. It is a rare disease, constituting about 2–5% of all leukemia cases. [1] It mostly involve myeloid with either of T lymphocyte or B lymphocyte progenitors, but in rare cases all the three cell lineages. [2]

Apr 16, 2015 · In adult patients, MPAL is characterized by relative therapeutic resistance that may be attributed in part to the high proportion of patients with adverse cytogenetic abnormalities. No prospective, controlled trials exist to guide therapy.

Mixed phenotype acute leukemia (MPAL) is when more than one type of leukemia occurs at the same time. Learn about the causes, symptoms, and treatments.

Jul 12, 2024 · Mixed phenotype acute leukemia (MPAL) refers to acute leukemias that cannot be unequivocally assigned to one hematopoietic lineage because the malignant blasts express both myeloid and lymphoid antigens. MPAL has previously been described as bilineage leukemia and biphenotypic acute leukemia.

Feb 5, 2021 · Purpose of review: Mixed phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia with features of both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The review examines current definitions and controversies in classification of MPAL, new insights into genomic drivers and pathogenesis, recent evidence to ...

Nov 5, 2024 · MPAL is a rare and heterogenous subtype of acute leukemia characterized by a single blast population with phenotypic expression of both myeloid and lymphoid lineages (biphenotypic) or multiple co-existing lineages of blasts that satisfy criteria for both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).

Mar 17, 2011 · We document for the first time the disease features on a large series of acute leukemia cases classified as MPAL according to the strict criteria established by the WHO 2008. 1 Our data show that MPAL includes rather heterogeneous acute leukemia cases. It affects both adults and children, including infants, although it seems more frequent in ...