2024年12月25日 · MRE11 (MRE11 Homolog, Double Strand Break Repair Nuclease) is a Protein Coding gene. Diseases associated with MRE11 include Ataxia-Telangiectasia-Like Disorder 1 and Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia .

2024年1月16日 · mre11功能的破坏会导致dna损伤耐受、免疫抑制并加速肿瘤发生。mre11促进dsdna激活cgas的新功能独立于其核酸酶活性和atm信号传导。 mrn复合物 与核小体片段的结合从核小体ap表面释放cgas，这使得cgas能够动员、细胞质重新定位并被dsdna激活。这些mre11依赖 …

MRE11-RAD50-NBS1（MRN）复合物可以识别并结合DSB，然后募集并激活ATM。激活的ATM可以磷酸化CtIP（C-terminal-binding protein interacting protein），再与BRCA1（乳腺癌相关蛋白1）相互作用，形成BRCA1 / MRN / CtIP复合体，促进DNA末端切除，以形成单链DNA，从而促进 HR （同源重组 ...

Double-strand break repair protein MRE11 (Meiotic recombination 11) is an enzyme that in humans is encoded by the MRE11 gene. [5] The gene has been designated MRE11A to distinguish it from the pseudogene MRE11B that is nowadays named MRE11P1.

2024年1月10日 · We demonstrate that binding of the MRE11–RAD50–NBN complex to nucleosome fragments is necessary to displace cGAS from acidic-patch-mediated sequestration, which enables its mobilization and...

2011年1月21日 · The MRE11 complex, consisting of meiotic recombination 11 (MRE11), RAD50 and Nijmegen breakage syndrome 1 (NBS1; also known as nibrin), is of key importance in the DNA damage response to DNA...

同源重组修复是精确的修复DSB的方式,MRE11-RAD50-NBS1 (MRN)复合物是参与同源重组修复的关键蛋白,在不同物种之间存在保守性。 从前关于MRN复合物的功能研究主要来源于酿酒酵母和线虫等低等生物,近些年来对哺乳动物MRN复合物的研究提示MRN复合物在高等动物DNA损伤修复中存在功能。 本文综述了MRN复合物的组成和结构及其在DNA损伤同源重组修复中的功能,同时也介绍了MRN复合物异常所带来的人类疾病共济失调性毛细血管扩张综合征类似病症、奈梅亨断 …

2023年12月20日 · Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in response to DNA damage and dependent on ATM phosphorylation of the latter. MRE11 lactylation promotes its binding to DNA, facilitating DNA end resection and HR.

Mre11 stabilizes Nbs1 and Rad50 and MRN activates Chk2 downstream from ATM in response to replication-mediated DNA double strand breaks; MRE11 is a new common target in the mismatch repair deficient tumorigenesis and has a role in colorectal carcinogenesis; Functional and structural characterization of a nuclease-deficient Mre11 protein termed ...

mre11 同系物，双链断裂修复核酸酶： 该基因编码一种参与同源重组、端粒长度维持和 dna 双链断裂修复的核蛋白。 该蛋白质本身具有 3' 至 5' 核酸外切酶活性和核酸内切酶活性。