2023年12月1日 · The results demonstrate that ABs derived from MSCs inhibited osteoclast differentiation and alveolar bone resorption. miRNA array analysis showed that miR-223-3p is highly enriched in those ABs and is critical for their therapeutic effects.

2023年12月1日 · The results demonstrate that ABs derived from MSCs inhibited osteoclast differentiation and alveolar bone resorption. miRNA array analysis showed that miR-223-3p is highly enriched in those...

MSC-ABs (500–2000 nm) are produced by apoptotic MSCs which undergo plasma membrane deformation and sprout vesicle structures directly, but not membrane fusion. The enhanced hydrostatic pressure in apoptotic MSCs breaks organelles and other substances into fragments, which are packaged into different vesicles.

2023年12月1日 · In this study, cytokine licensing was used to enhance the immunomodulatory potency of MSCs and ABs derived from licensed MSCs in vitro were isolated to explore their immunomodulatory effects as an effective non-viable cell therapy.

ABs derived from IFN-γ/TGF-β1-licensed apoptotic MSCs significantly inhibited T cell proliferation, induced more regulatory T cells, and maintained immunomodulatory T cells but reduced pro-inflammatory T cells.

研究表明，MSC 衍生的分泌组包括分泌蛋白、外泌体、凋亡小体 (AB) 和其他大分子，可能具有与亲本 MSC 类似的治疗效果。 在 MSC 衍生的分泌组的所有成分中，迄今为止最受关注的是外泌体的治疗潜力。 然而，由于有报道MSCs在体内移植后发生凋亡并释放ABs，我们推测ABs是否具有免疫调节作用。 在本研究中，细胞因子许可用于增强 MSC 的免疫调节效力，并在体外分离来自许可 MSC 的 AB，以探索其作为有效的非活细胞疗法的免疫调节作用。 IFN-γ和IFN-γ/TGF-β1 …

2023年12月1日 · The results demonstrate that ABs derived from MSCs inhibited osteoclast differentiation and alveolar bone resorption. miRNA array analysis showed that miR-223-3p is highly enriched in those...

Herein, in a myocardial infarction (MI) model, we found that transplanted MSCs released apoptotic bodies (ABs) to enhance angiogenesis and improve cardiac functional reclovery via regulating macroautophagy/autophagy in the recipient endothelial cells (ECs).

2025年3月7日 · Additionally, apoptotic body-deficient MRL/lpr mice were analyzed to evaluate the direct contribution of OC-ABs to OA progression and subchondral bone remodeling. The involvement of OC-ABs in osteogenesis was further examined using mesenchymal stem cells (MSCs), with a focus on the RANKL reverse signaling pathway.

In the wake of bone injury, osteoblasts and OCs within the primary bone tissue undergo natural apoptosis or perish, contributing cellular contents or apoptotic bodies (ABs) that play a role in the inflammatory process and influence the differentiation of MSCs.