2024年12月25日 · MSRB2 (Methionine Sulfoxide Reductase B2) is a Protein Coding gene. Diseases associated with MSRB2 include Neu-Laxova Syndrome 2 and Batten-Turner Congenital Myopathy. Among its related pathways are Protein repair and Metabolism of proteins.

We now report that the mitochondrial matrix protein MsrB2 plays an important role in switching on mitophagy by reducing Parkin methionine oxidation (MetO), and transducing mitophagy through ubiquitination by Parkin and interacting with LC3.

Methionine-R-sulfoxide reductase B2, mitochondrial is an enzyme that in humans is encoded by the MSRB2 gene. [5] [6] [7] The MRSB2 enzyme catalyzes the reduction of methionine sulfoxide to methionine.

预测启用肌动蛋白结合活性；肽甲硫氨酸 (R) -S-氧化物还原酶活性；和锌离子结合活性。 预计参与肌动蛋白丝聚合和蛋白质修复。 预测位于线粒体中。 预计在细胞质中有活性。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair.

2025年2月8日 · MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis. Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy.

2024年12月28日 · 本文将详细介绍MSRB2基因的意义和作用，包括其功能、相关疾病、研究进展以及在医学中的应用前景。 什么是MSRB2基因？ MSRB2基因，全名是methionine sulfoxide reductase B2 ，它位于人类染色体10p12.2位置。这个基因编码一种蛋白质，主要负责修复被氧化的甲硫氨酸（methionine），这是一种在蛋白质中常见的 ...

Methionine sulfoxide reductase B2 (MSRB2) is a mitochondrial protein that protects cell from oxidative stress. The antioxidant activity suggests that MSRB2 may play a role in the pathophysiology of Alzheimer's disease (AD). Here, we report that in APP/PS1 mice, an animal model of AD, MSRB2 protein l …

2024年7月5日 · Methionine sulfoxide reductase B2 (MsrB2) can reverse oxidation induced MetO in mitochondrial proteins, so we investigated its role in diabetic cardiomyopathy. We observed that DM-induced heart damage in diabetic mice model is characterized by increased ROS, increased protein MetO with mitochondria structural pathology, and cardiac fibrosis.

Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy. the role for mitochondrial MSRB2 in Alzheimer's disease pathology is indispensible.

Here, we report the solution structure of reduced Mus musculus MsrB2 using high resolution nuclear magnetic resonance (NMR) spectroscopy. MsrB2 is a β-strand rich globular protein consisting of eight antiparallel β-strands and three N-terminal α-helical segments.