Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans is encoded by the MST4 gene. [5] The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20 -like kinases.

2018年1月22日 · mst4是哺乳动物 stk丝氨酸/苏氨酸激酶家族的成员。 已知mst4激活p-erk以诱导细胞生长和转化，并促进前列腺癌、肝细胞癌的上皮-间充质转变和癌症转移的进展。同时，mst4也通过磷酸化traf6与炎症反应相关联。 然而，mst4在肿瘤自噬中的作用尚未得到证实。

2023年10月13日 · Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder in which macrophages play a critical role. Mammalian sterile-20-like kinase 4 (MST4), a member of the germinal-center...

2013年2月28日 · 该研究阐述了支架蛋白mo25对ste20家族激酶mst4的激活机制。 mst4属于ste20激酶gckiii亚家族，在细胞极性、增值、转化与迁移等过程中发挥重要作用。mo25与假激酶strad共同激活肿瘤抑制蛋白lkb1，从而使得lkb1发挥抗肿瘤的生物学活性。

2023年6月1日 · MST4, a serine/threonine-protein kinase, plays a crucial role in regulating cell migration and polarity in normal and tumor cells. MST4 modulates ERK and AKT signaling pathways to facilitate tumor cell proliferation, migration, invasion, EMT, survival, and metastasis.

2015年5月13日 · 该项研究揭示了mst4在天然免疫中的重要功能与作用机制，为免疫炎症相关疾病的诊疗提供了新的思路。 相关研究成果已申请专利。 近年来，周兆才研究组围绕STRIPAK这一“激酶-磷酸酶”超分子复合物，展开癌症与炎症信号转导方面的系统性研究，取得了阶段性 ...

2015年2月2日 · Here we report that germinal center kinase MST4 responded dynamically to bacterial infection and acted as a negative regulator of inflammation. We found that MST4 directly interacted with and...

We verify the effects of MST4 on irradiation-induced gastric death, and also investigate effects of MST4 activating autophagy in GC cell lines with various in vitro assays using western blotting. Results: We have confirmed the high transcription level of MST4 from TCGA, USLCAN, HPA, and other portals, but a rapid decrease in protein level.

2020年11月19日 · Knockdown of MST4 activated epithelial-mesenchymal transition (EMT) process, significantly increasing the ability of invasion and migration in choriocarcinoma cell lines (JAR and JEG-3). In contrast, the EMT process was restrained in choriocarcinoma cell lines with overexpressed MST4 .

2022年12月15日 · The mammalian STE 20-like protein kinase 4 (MST4) gene is highly expressed in several cancer types, but little is known about the role of MST4 in breast cancer, and the function of MST4 during epithelial-mesenchymal transition (EMT) has not been fully elucidated. Here we report that overexpression o …