Melatonin activates two high-affinity G protein–coupled receptors, termed MT 1 and MT 2, to exert beneficial actions in sleep and circadian abnormality, mood disorders, learning and memory, …

2024年12月25日 · Type 1 family. Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are …

2021年11月4日 · Accumulating experimental data from studies with MT-deficient mice or human samples has demonstrated the critical immunoregulatory role of MT isoforms in cancer, …

2022年11月15日 · Across four independently derived Dnmt3a;Npm1-mutant AMLs, metallothionein 1 (Mt1) was the top common, significantly upregulated transcript in the most …

Upstream of these events, the Zn-sensing metal-response element-binding transcription factor-1 (MTF-1) regulates MT expression to maintain precision in the size of the intracellular free Zn …

2020年8月22日 · The present study showed that metallothionein-1 (MT-1), which is a low molecular weight protein that is involved in the detoxification of heavy metals and scavenging …

具有铜离子结合活性。参与神经元凋亡过程的负调控。在几个过程的上游或内部发挥作用，包括细胞对铬酸盐的反应；细胞对锌离子的反应；以及细胞锌离子内稳态。位于细胞质和溶酶体中。 …

2025年2月8日 · MT-1 might manifest as a protein involved in immunosuppression of rheumatoid arthritis pathogenesis by shifting Th17/Treg balance and may prove to be a potential …

MT-1镜筒透镜允许在成像路径中引入分光镜，从而实现自定义的同轴照明系统配置。MT-2镜筒透镜与MT-1类似，但有效焦距为400mm，能将任一三丰(Mitutoyo)物镜的标称放大倍数乘以2 …

Here, we review the role of the MT 1 receptor in neuropsychopharmacology, describe the anatomical localization of MT 1 receptors in the brain, discuss the medicinal chemistry, …