2018年7月25日 · Bidirectional transcription of mitochondrial DNA (mtDNA) is an extreme example of convergent transcription in mammalian cells owing to symmetrical synthesis of both...

Background and aims: Mitochondrial double-stranded RNA (mtdsRNA) and its innate immune responses have been reported previously; however, mtdsRNA generation and its effects on …

2024年8月27日 · Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent cells and a critical driver of their inflammatory secretome, known as …

2018年8月13日 · Various studies have identified key pathways that prevent mitochondrial DNA (mtDNA) from escaping into the cytoplasm; Nicholas Proudfoot and colleagues now describe …

Loss of either enzyme results in massive accumulation of mitochondrial double-stranded RNA that escapes into the cytoplasm in a PNPase-dependent manner. This process engages an MDA5 …

2024年7月2日 · In addition to mitochondrial DNA, mitochondrial double-stranded RNA (mtdsRNA) is exported from mitochondria. However, specific channels for RNA transport have not been …

Here, we test the hypothesis that leaked mitochondrial (mt) double-stranded (ds)RNA is recognized as foreign nucleic acid, which triggers innate immune signaling, APOBEC3A …

Mitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. …

2024年8月8日 · Impaired mitophagy in aged or injured neurons leads to the accumulation of dysfunctional mitochondria, which release mitochondrial-derived damage-associated …

2022年12月16日 · Studies have shown that MDA5 is a major sensor of mtdsRNA. The immune response induced by mtdsRNA is mediated through the MDA5-MAVS axis and results in the …