What are MTR/MTRR gene mutations and methionine synthase reductase? MTRR (Methionine synthase reductase) helps recycle B12 by producing an enzyme called methionine synthase reductase. The combination of MTR and MTRR mutations can deplete methyl B12.

5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (MTRR) is an enzyme which interacts with methionine synthase, to ensure the continued production of the essential amino acid methionine, and is encoded for by the MTRR gene 1.

The MTRR gene is essential as it encodes the enzyme methionine synthase reductase, which plays a critical role in homocysteine metabolism and DNA methylation. Its proper function is important for maintaining cellular health and preventing various diseases.

The MTRR gene is associated with a family of electron transferases known as the Ferredoxin-NADP(+) reductase (FNR) family. Found in 15 primates and over 16 tissues in humans, MTRR is 34 kb long. [12] The gene comprises 15 exons and includes numerous cytolosic mitochondrial mRNA isoforms.

The MTRR gene provides instructions for making an enzyme called methionine synthase reductase. Learn about this gene and related health conditions.

2018年11月19日 · MTR (methionine synthase) and MTRR (methionine synthase reductase) code for two enzymes that work together in the methylation cycle. The MTR gene works in the final step to regenerate homocysteine into methionine using methyl-B12 (methylcobalamin)

2024年12月25日 · MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase) is a Protein Coding gene. Diseases associated with MTRR include Homocystinuria-Megaloblastic Anemia, Cble Type and Neural Tube Defects, Folate-Sensitive.

2024年10月29日 · What is the MTRR Gene? The MTRR gene on chromosome 5 produces an enzyme vital for turning homocysteine into methionine. This process supports DNA methylation and protein production. When MTRR mutations happen, they can mess up DNA methylation and lead to different health problems. What is the Normal Function of the MTRR Gene? The MTRR …

2018年2月6日 · The MTRR gene, also known as the ‘methionine synthase reductase’ gene is located on chromosome 5. This gene is responsible for maintaining adequate levels of activated vitamin B12 (methylcob(III)alamin), which maintains …

The MTRR gene provides instructions for making an enzyme called methionine synthase reductase. This enzyme is required for the proper function of another enzyme called methionine synthase. Methionine synthase helps process amino acids, which are the building blocks of …