Multinucleate cells (also known as multinucleated cells or polynuclear cells) are eukaryotic cells that have more than one nucleus, i.e., multiple nuclei share one common cytoplasm. Mitosis in multinucleate cells can occur either in a coordinated, synchronous manner where all nuclei divide simultaneously or asynchronously where individual ...

Initially, we established conditions to quickly and easily generate multinucleated cells by seeding a Xenopus tadpole epithelium tissue-derived cell line (XTC-YF) on less and more hydrophilic dishes, and incubating the cultures with medium supplemented with or without Y-27632—a ROCK inhibitor—to reduce cell contractility.

2012年10月2日 · With respect to advantages, a multinucleated cell makes sense when the speed of intracellular signalling is important (e.g., calcium diffusion). It may also be useful in the case of cells when the cell needs to coordinate the synthesis of large amounts of protein.

MGCs are multinuclear cells of monocyte origin. Although they are the hallmark in the neoplastic processes of GCLJ and GCT, they may also arise in other pathologic lesions, e.g. in tissue response to foreign bodies and autoimmune disorders. Differences in MGC subtyping in these various conditions are almost lacking.

2024年11月27日 · Cell–cell fusion is a vital biological process where the membranes of two or more cells merge to form a syncytium. This phenomenon is critical in various physiological and pathological contexts, including embryonic development, tissue repair, immune responses, and the progression of several diseases.

2022年11月1日 · Here, we review a subset of the developmental contexts in which the regulation of the movement and positioning of multiple nuclei are well understood, including pronuclear migration, the Drosophila syncytial blastoderm, the Caenorhabditis elegans hypodermis, skeletal muscle and filamentous fungi.

In this review, we describe and compare the phenotypic aspects, biological and functional activities of the three types of multinucleated giant cells. Furthermore, we provide an overview of the multinucleation process and highlight key molecules …

2023年11月21日 · Rather than possessing only a single nucleus, multinucleated cells contain more than one nucleus. There are many examples of multinucleated cells in humans, some associated with normal...

2018年6月11日 · Many types of large cells have multiple nuclei. In skeletal muscle fibers, the nuclei are distributed along the cell to maximize their internuclear distances. This myonuclear positioning is crucial for cell function. Although microtubules, microtubule associated proteins, and motors have been implic …

2018年1月4日 · Are there examples of cells with more than one nucleus? Yes, they are called Multinucleate cells. There are two types of multinucleated cells. Syncytia; Coenocytes; I highly recommend having a look at this answer for the definitions. Examples of Syncytia include. Osteoclasts; Skeletal muscle fibers (thanks @kmm) Examples of Coenocytes include