Mas-related G protein coupled receptors (MRGPRs) family members play important roles in the sensation of noxious stimuli and represent novel targets for the treatment of itch and pain.

2024年1月9日 · MRGPR stimulation can trigger different immune processes, leading to the release of pro-inflammatory cytokines, chemotaxis of immune cells, and modulation of immune cell activation states. One of the main identified mechanisms for MRGPRs is facilitating the crosstalk between sensory nerves and immune cells.

Mrgprs (Mas-related G protein-coupled receptors, Mrg- prs) 是近年来新发现的一类由50 多个成员组成的G 蛋白偶联受体，主要表达在外周神经系统的背根神 经节 (dorsal root ganglion, DRG)、三叉神经节 (trigeminal ganglion, TG) 神经细胞以及肥大细胞上。

2021年4月1日 · Mas-related G protein-coupled receptors (Mrgprs) are key receptors involved in the regulation of such biological processes. First described more than 25 years ago, the Mrgpr family now comprises more than 50 members in humans and rodents. Many Mrgprs are still considered as orphan receptors, with no identified endogenous or synthetic ligands.

Pharmacological activation of Mrg proteins is capable of modulating sensory neuron activities and elicits nociceptive effects. In this study, we illustrate a control mechanism that allows the Runx1 runt domain transcription factor to generate compartmentalized expression of …

2023年4月1日 · Mas-related G protein-coupled receptors (MRGPRs) primarily function as itch and pain receptors and display diverse downstream signaling pathways. MRGPRs are fast-evolving proteins with highly diverse amino acid sequences across different species and display high allele frequencies of the missense mutations in humans.

GO分析结果表明，差异表达的MRGs主要富集于小分子分解代谢过程、羧酸生物合成过程、有机酸生物合成过程、细胞氨基酸代谢过程、α-氨基酸代谢过程、酒精代谢过程、有机酸分解代谢过程、羧酸分解代谢过程、辅酶结合和脂肪酸代谢过程（图2C）。 KEGG分析表明，差异表达的MRG在化学致癌、药物代谢——细胞色素P450、药物代谢——其他酶、细胞色素P450对异生物质的代谢、嘌呤代谢、视黄醇代谢、氨基酸生物合成、辅因子生物合成、 谷胱甘肽 的代谢中显着积累 …

Incidence and clinical outcomes of perforations during mechanical thrombectomy for medium vessel occlusion in acute ischemic stroke: a retrospective, multicenter, and … AA Dmytriw, B …

2023年11月26日 · 为此， 提出一种新的多模态关系图网络(MRG-Net)方法，通过潜在特征空间中的交互消息传播，动态融合视觉和运动学信息 。 主要工作： 1. 首先，用 时间卷积网络和LSTM单元 从视频和运动学序列中 提取embedding(嵌入序列） 。 2.

MAS-related G-protein coupled receptor, D (MRGD), also referred to as hGPCR45 [9] or TGR7 [10], was identified as a novel GPCR in murine and human genomes [11]. It was found that MRGD serves as the receptor of beta-alanine [12].