The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell.

MyD88是TLR/MyD88/NF-κB信号通路中一个重要的接头蛋白分子，可以使信号向下游转导的的一个重要节点。 MyD88在多种组织细胞中均有表达，如肝、肾、脾脏、肌肉组织，以及单核细胞、胸腺细胞等。 MyD88实际上是一种胞质可溶性蛋白，整个结构由3个功能区域组成，包括C-端的TIR结构域、中间域以及N端的死亡域。 C-端的TIR结构域含有130个氨基酸，主要是通过与蛋白质结合，向下游传递信号，N-端的死亡结构域含有90个氨基酸，负责招募下游具有死亡结构域的 …

MyD88 简介. 髓样分化因子88(MyD88)是一种蛋白质，由 MYD88基因 编码。该基因为制造一种参与免疫细胞内信号传递的蛋白质提供指令。MyD88蛋白作为一个适配器，将接收细胞外信号的蛋白质与细胞内转播信号的蛋白质连接起来。

MyD88 is the canonical adaptor for inflammatory signaling pathways downstream of members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families. MyD88 links IL-1 receptor (IL-1R) or TLR family members to IL-1R-associated kinase ...

The MYD88 gene provides instructions for making a protein involved in signaling within immune cells. The MyD88 protein acts as an adapter, connecting proteins that receive signals from outside the cell to the proteins that relay signals inside the cell.

2020年11月25日 · Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling pathways. TLR/IL-1R pathways regulate the proliferation and differentiation of ce …

2016年11月28日 · MyD88 is a 296 amino acid cytoplasmic adaptor protein that relays signals from IL-1, IL-18, IFNγ, IL-33, and most TLRs. MyD88 transcript is detected in most tissues including the heart, brain, spleen, lung, liver, muscle, kidney, and testis, as well as in the T, B, and myeloid cell lines.

MyD88 is suppressed by Trichinella spiralis excretory-secretory products via the mannose receptor in human macrophages and in a mouse model of polymicrobial sepsis; MYD88 mutations, especially L265P, are very frequent in Vitreoretinal lymphoma and their detection significantly improves the diagnostic yield of vitrectomy specimens.

2024年3月11日 · 髓样分化因子88（MyD88）是固有免疫信号传导中的关键转接蛋白，参与toll样受体信号通路、NF-κB信号通路和MAPK信号通路。 不仅在细胞再生、去分化、表型转化等细胞生理活动中发挥重要作用，还参与细胞坏死及炎症反应。 近年来发现MyD88-L265P突变与B细胞淋巴瘤高度关联。 髓样分化因子88 (MyD88)，被认为是固有免疫信号传导中的关键转接蛋白，是上游TLRs/IL-1R 和下游NF-κB通路信号转导的桥梁，不仅在细胞再生、去分化、表型转化等细胞生 …

2018年5月15日 · MYD88 is a driver gene found in hematologic B-cell malignancies. A missense mutation (L265P) changing leucine at position 265 to proline in MYD88 is found in ∼90% of Waldenström macroglobulinemia (WM) cases and in significant portions of activated B-cell diffuse large B-cell lymphomas and IgM monoclonal gammopathy of undetermined significance.