2024年12月25日 · This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is …

Myb-binding protein 1A is a protein that in humans is encoded by the MYBBP1A gene. [5] [6]

2025年2月9日 · MYBBP1A functions to enhance p53 tetramerization that is necessary for p53 activation. Mybbp1a is a novel negative regulator of Sirt7. Regulators, including BCL11A, …

Significance: Mybbp1a was shown to be an important regulator of cellular proliferation, related to RNA Pol II genes. We link its function now as well to regulating RNA Pol I genes and to control …

In this study, we demonstrated that MYBBP1A enhances p53 tetramerization, followed by acetylation under nucleolar stress. We found that MYBBP1A has two regions that directly bind …

2020年1月20日 · The MYB binding protein 1A (MYBBP1A, also known as p160) acts as a co-repressor of multiple transcription factors involved in many physiological processes. Therefore, …

2003年9月10日 · In this study we show that Mybbp1a is a nucleocytoplasmic shuttling protein and investigate the mechanisms responsible for both nuclear import and export.

2012年7月13日 · In this study we discovered that Mybbp1a is associated with both the RNA polymerase I complex and the ribosome biogenesis machinery. Using a reporter assay that …

2025年2月8日 · Mybbp1a is a nucleocytoplasmic shuttling protein involved in nuclear import and export via CRM1-dependent and -independent pathways. Enables E-box binding activity and …

MYBBP1A is a ubiquitous 160 kDa protein, first identified for its binding and repression of the proto-oncogene c-MYB. Since then, it has been found that MYBBP1A acts as a co-repressor …