2024年12月25日 · MYCL (MYCL Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYCL include Hematologic Cancer and Lung Cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is MYCN.

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. [5] [6] MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer. [7]

MYCL1 Amplification and Expression of L-Myc and c-Myc in Surgically Resected Small-Cell Lung Carcinoma. These results suggest that Mycl1 expression might be useful as a biomarker to predict prognosis and is a promising therapeutic target for patients with gastric cancer.

Identification of the frequency of C-MYC and MYCL1 expression among SCLC patients may help to identify potential targets for therapeutic intervention. Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.

2021年6月18日 · Identification of the frequency of C-MYC and MYCL1 expression among SCLC patients may help to identify potential targets for therapeutic intervention. Our aim was to detect MYCL1 amplification, L-Myc and c-Myc expression, and investigate clinicopathological characteristics and survival status in patients with surgically resected SCLC.

本项目拟利用CRISPR/Cas9、RNA干扰、类器官培养、人源化动物模型等技术，研究MYCL1在SCLC发生及肿瘤维持中的作用，并通过RNA-seq、ChIP-seq等分析鉴定MYCL1在SCLC中的下游基因。

2025年2月8日 · The MYCL and MXD1 transcription factors regulate the fitness of murine dendritic cells. This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation.

Another MYC family member, L-myc (MYCL1), was found to be amplified in small cell lung carcinomas (Nau et al. 1985). Therefore all three vertebrate MYC family genes (MYC, MYCN, and MYCL1) are linked to the etiology of human cancers. Figure 1 summarizes several modes of MYC gene family deregulation.

预测可实现 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。 预计参与 RNA 聚合酶 II 的转录调控。 预计在内耳听觉受体细胞分化的调节上游或调节内起作用。 位于染色体和核质中。 [由基因组资源联盟提供，2022 年 4 月] Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity.

2024年10月9日 · MYCL1（MYCL proto-oncogene, bHLH transcription factor 1）蛋白是属于Myc家. 族的原癌基因之一。Myc基因家族成员包括MYC、MYCN和MYCL1，它们在细胞. 增殖、分化、凋亡和代谢中发挥重要的转录调控作用。MYCL1基因编码一种具有