2013年12月20日 · In the present study, we found that ALK directly mediates MYCN-induced oncogenic properties. The promoter region of ALK gene contains a non-canonical E-box located upstream of the...

2018年12月11日 · We show that mutant ALK downregulates the ‘HMG-box transcription factor 1’ (HBP1) through the PI 3 K-AKT–FOXO3a signaling axis. HBP1 inhibits both the transcriptional activating and repressing...

The second-generation ALK inhibitor alectinib effectively induces apoptosis in human neuroblastoma cells and inhibits tumor growth in a th-MYCN transgenic neuroblastoma mouse model.

靶向治疗具有特异性强、灵敏度高、毒副作用小等特点，是肿瘤治疗研究的新方向。 本文主要对MYCN基因、ALK基因相关靶向药物在神经母细胞瘤治疗试验中的研究进展进行综述。

Mutations of ALK are frequently observed in MYCN -amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.

2013年11月1日 · We review the latest approaches envisioned for blockade of ALK activity in neuroblastoma, present a classification of potential approaches for therapeutic targeting of MYCN, and discuss how recent developments in targeting of MYC proteins appear to make therapeutic inhibition of MYCN a reality in the clinic.

2025年3月7日 · The activation of PI3K–AKT by ALK creates a signalling crosstalk that further potentiates the activity of MYCN, thus possibly explaining why neuroblastomas with ALK mutations and MYCN ...

In the present study, we found that ALK directly mediates MYCN-induced oncogenic properties. The promoter region of ALK gene contains a non-canonical E-box located upstream of the transcription initiation site, and MYC proteins bind onto …

2024年3月26日 · Huang et al. used a human stem cell model to elucidate the mechanism for cooperation between MYCN and ALK. ALK contributes to tumor growth by upregulating the extracellular matrix protein periostin and activating WNT signaling. Periostin and WNT signal through a feedforward loop.

Our study showed a novel coordinately prognostic role of <i>ALK</i> and <i>MYCN</i> protein expression in neuroblastoma and is the first report to demonstrate the correlation between <i>ALK</i> and <i>MYCN</i> protein expression in primary neuroblastoma tumours.