2019年11月1日 · Our findings demonstrate a critical role for PA2G4 as a cofactor in MYCN-driven neuroblastoma and highlight competitive inhibition of the PA2G4-MYCN protein binding as a …

We have identified a protein called PA2G4, which is a cofactor for MYCN in promoting cancer cell growth. We have developed a compound WS6 and its analogous, which inhibits PA2G4 and …

2024年6月4日 · PA2G4 is involved in protein translation, cell cycle progression 41, 42, 43, and a cancer-druggable feed-forward transcriptional regulator of MYCN in neuroblastoma 44.

2023年3月17日 · MYCN is a major oncogenic driver for neuroblastoma tumorigenesis, yet there are no direct MYCN inhibitors. We have previously identified PA2G4 as a direct protein …

2024年10月14日 · We recently identified Proliferation-Associated protein 2G4 (PA2G4) as a direct protein-binding partner of MYCN which acts in a forward feedback expression loop with...

2019年9月9日 · Our findings demonstrate a critical role for PA2G4 as a cofactor in MYCN-driven neuroblastoma and highlight competitive inhibition of the PA2G4-MYCN protein binding as a …

在这里，我们揭示了新型MYCN靶标和结合蛋白，增殖相关2AG4（PA2G4）的致癌作用。 染色质的免疫沉淀研究表明，MYCN占据了PA2G4基因启动子，刺激了转录。

2020年11月20日 · Our studies revealed that PA2G4 was able to bind directly to MYCN, leading to an oncogenic forward feedback loop of high expression levels of PA2G4-p48 and MYCN …

2019年11月1日 · Treated tumors showed reduced levels of both MYCN and PA2G4. Our findings demonstrate a critical role for PA2G4 as a cofactor in MYCN-driven neuroblastoma and …

2023年3月17日 · We have previously identified PA2G4 as a direct protein-binding partner of MYCN and drive neuroblastoma tumorigenesis. A small molecule known to bind PA2G4, WS6, …