The Evolutionary Aspects of Aquaporin Family - PubMed
They are grossly divided into three subfamilies based on the sequence around a highly conserved pore-forming NPA motif: (1) classical water -selective AQP (CAQP), (2) glycerol -permeable …
Adaptive Selection in the Evolution of Aquaglyceroporins in …
2023年5月7日 · Six exons encoding the functional MIP domain of AQGP genes were found to be conserved across mammalian species. Evolutionary analysis indicated signatures of positive …
Clinical value and molecular mechanism of AQGPs in different …
2022年8月16日 · Overexpression or knockdown of AQGPs can promote or inhibit cancer cell proliferation, migration, invasion, apoptosis, epithelial–mesenchymal transition and metastasis, …
MYL9：肌球蛋白“细胞动力马达”家族一员，癌细胞迁移动力靶点？ …
2023年7月12日 · 肌球蛋白监管轻链MYL9（myosin regulatory light chain 9，又称MLC2, MRLC1或MLC-2C）是组成肌球蛋白的调节性轻链。 人MYL9基因位于染色体20q11.23上，包 …
哺乳动物水甘油孔蛋白进化中的适应性选择,Journal of Molecular …
水通道蛋白 (aqp) 是一种完整的膜蛋白，负责原核生物和真核生物中水跨细胞膜的运输。aqp 的一个亚家族，称为水甘油孔蛋白 (aqgp)，促进甘油、水和其他溶质等小溶质跨细胞膜的运输。这 …
Adaptive Selection in the Evolution of Aquaglyceroporins in …
2023年5月7日 · In the present study, 119 AQGP coding sequences from 31 mammalian species were analysed to identify conserved residues, gene organisation, and most importantly, the …
Clinical value and molecular mechanism of AQGPs in different …
2022年8月16日 · Overexpression or knockdown of AQGPs can promote or inhibit cancer cell proliferation, migration, invasion, apoptosis, epithelial-mesenchymal transition and metastasis, …
Aquaglyceroporin AQP7's affinity for its substrate glycerol. Have …
2022年1月1日 · AQP7 is one of the four human aquaglyceroporins that facilitate glycerol transport across the cell membrane, a biophysical process that is essential in human physiology.
E环半螺旋中螺旋内盐桥的存在会影响AQP1和GlpF通道的转运特 …
主要内在蛋白（mip）超家族包含水传输aqp1和甘油特异性glpf，它们属于两个主要系统发育组，即水通道蛋白（aqp）和水甘油通道蛋白（aqgp）。 MIP通道具有六个跨膜螺旋（TM1至TM6） …
Structural features of the aromatic/arginine constriction in the ...
Glycerol transport across the cell membrane is mediated by aquaglyceroporins (AQGPs), whereas our previous study revealed that it was disfavoured by GintAQPF2, an AQGP from …